2eqr: Difference between revisions

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[[Image:2eqr.jpg|left|200px]]


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==Solution structure of the first SANT domain from human nuclear receptor corepressor 1==
The line below this paragraph, containing "STRUCTURE_2eqr", creates the "Structure Box" on the page.
<StructureSection load='2eqr' size='340' side='right'caption='[[2eqr]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2eqr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EQR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EQR FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eqr OCA], [https://pdbe.org/2eqr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eqr RCSB], [https://www.ebi.ac.uk/pdbsum/2eqr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eqr ProSAT], [https://www.topsan.org/Proteins/RSGI/2eqr TOPSAN]</span></td></tr>
{{STRUCTURE_2eqr| PDB=2eqr |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/NCOR1_HUMAN NCOR1_HUMAN] Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.<ref>PMID:14527417</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eq/2eqr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eqr ConSurf].
<div style="clear:both"></div>


'''Solution structure of the first SANT domain from human nuclear receptor corepressor 1'''
==See Also==
 
*[[Nuclear receptor corepressor|Nuclear receptor corepressor]]
 
== References ==
==About this Structure==
<references/>
2EQR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EQR OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hayahsi, F.]]
[[Category: Hayahsi F]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: Zhang HP]]
[[Category: Zhang, H P.]]
[[Category: N-cor]]
[[Category: N-cor1]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Nuclear receptor corepressor 1]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Sant domain]]
[[Category: Structural genomic]]
[[Category: Transcription]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:00:39 2008''

Latest revision as of 21:54, 29 May 2024

Solution structure of the first SANT domain from human nuclear receptor corepressor 1Solution structure of the first SANT domain from human nuclear receptor corepressor 1

Structural highlights

2eqr is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

NCOR1_HUMAN Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J. N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. Mol Cell. 2003 Sep;12(3):723-34. PMID:14527417
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