2dn6: Difference between revisions
New page: left|200px<br /> <applet load="2dn6" size="450" color="white" frame="true" align="right" spinBox="true" caption="2dn6" /> '''Solution structure of the PH domain of KIAA... |
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== | ==Solution structure of the PH domain of KIAA0640 protein from human== | ||
<StructureSection load='2dn6' size='340' side='right'caption='[[2dn6]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2dn6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DN6 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dn6 OCA], [https://pdbe.org/2dn6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dn6 RCSB], [https://www.ebi.ac.uk/pdbsum/2dn6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dn6 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dn6 TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SWP70_HUMAN SWP70_HUMAN] Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).<ref>PMID:10681448</ref> <ref>PMID:12925760</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dn/2dn6_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dn6 ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Inoue | [[Category: Inoue M]] | ||
[[Category: Kigawa | [[Category: Kigawa T]] | ||
[[Category: Koshiba | [[Category: Koshiba S]] | ||
[[Category: Li | [[Category: Li H]] | ||
[[Category: Tochio N]] | |||
[[Category: Tochio | [[Category: Yokoyama S]] | ||
[[Category: Yokoyama | |||
