2dn6

Solution structure of the PH domain of KIAA0640 protein from humanSolution structure of the PH domain of KIAA0640 protein from human

Structural highlights

2dn6 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR, 20 models
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

SWP70_HUMAN Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Masat L, Caldwell J, Armstrong R, Khoshnevisan H, Jessberger R, Herndier B, Wabl M, Ferrick D. Association of SWAP-70 with the B cell antigen receptor complex. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2180-4. PMID:10681448 doi:http://dx.doi.org/10.1073/pnas.040374497
↑ Hilpela P, Oberbanscheidt P, Hahne P, Hund M, Kalhammer G, Small JV, Bahler M. SWAP-70 identifies a transitional subset of actin filaments in motile cells. Mol Biol Cell. 2003 Aug;14(8):3242-53. Epub 2003 Apr 17. PMID:12925760 doi:http://dx.doi.org/10.1091/mbc.E03-01-0043

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Masat L, Caldwell J, Armstrong R, Khoshnevisan H, Jessberger R, Herndier B, Wabl M, Ferrick D. Association of SWAP-70 with the B cell antigen receptor complex. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2180-4. PMID:10681448 doi:http://dx.doi.org/10.1073/pnas.040374497

[2] Hilpela P, Oberbanscheidt P, Hahne P, Hund M, Kalhammer G, Small JV, Bahler M. SWAP-70 identifies a transitional subset of actin filaments in motile cells. Mol Biol Cell. 2003 Aug;14(8):3242-53. Epub 2003 Apr 17. PMID:12925760 doi:http://dx.doi.org/10.1091/mbc.E03-01-0043

[1]

[2]

2dn6

Solution structure of the PH domain of KIAA0640 protein from humanSolution structure of the PH domain of KIAA0640 protein from human

Structural highlights

Function

Evolutionary Conservation

References

Contents

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

2dn6

Solution structure of the PH domain of KIAA0640 protein from humanSolution structure of the PH domain of KIAA0640 protein from human

Structural highlights

Function

Evolutionary Conservation

References

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

Search