User:Mathias Vander Eide/Sandbox 1: Difference between revisions
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==== Bypass Motif ==== | ==== Bypass Motif ==== | ||
The <scene name='10/1038869/Bypass_overview/3'>Bypass Motif</scene> is a series of residues in the midsection of the | The <scene name='10/1038869/Bypass_overview/3'>Bypass Motif</scene> is a series of residues in the midsection of the amylin peptide that are crucial for providing structural specificity for the AMYR. Without RAMP association, the CTR is in a relaxed, fluid state, allowing the binding of calcitonin. When RAMP binds the receptor, it is forced into a new, rigid conformation, which interferes with calcitonin binding. Amylin's bypass motif | ||
<scene name='10/1038869/Bypass_overview/3'>Bypass Motif</scene> | <scene name='10/1038869/Bypass_overview/3'>Bypass Motif</scene> | ||
<scene name='10/1038869/Sct_bypass/1'> | <scene name='10/1038869/Sct_bypass/1'>Calcitonin</scene> | ||
[[Image:SCT_rAmy_Overlay_v2.png|200 px|left|thumb|Overlay of sCT (orange) and rAmy (green)]] | [[Image:SCT_rAmy_Overlay_v2.png|200 px|left|thumb|Overlay of sCT (orange) and rAmy (green)]] | ||