8qfb: Difference between revisions

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'''Unreleased structure'''


The entry 8qfb is ON HOLD  until Paper Publication
==Crystal structure of human MPP8 C-terminal region (residues 565-860)==
 
<StructureSection load='8qfb' size='340' side='right'caption='[[8qfb]], [[Resolution|resolution]] 3.04&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8qfb]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QFB FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.04&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qfb OCA], [https://pdbe.org/8qfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qfb RCSB], [https://www.ebi.ac.uk/pdbsum/8qfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qfb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MPP8_HUMAN MPP8_HUMAN] Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression.<ref>PMID:20871592</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Modis Y]]
[[Category: Prigozhin DM]]

Latest revision as of 09:04, 11 September 2024

Crystal structure of human MPP8 C-terminal region (residues 565-860)Crystal structure of human MPP8 C-terminal region (residues 565-860)

Structural highlights

8qfb is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.04Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MPP8_HUMAN Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression.[1]

References

  1. ↑ Kokura K, Sun L, Bedford MT, Fang J. Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion. EMBO J. 2010 Nov 3;29(21):3673-87. doi: 10.1038/emboj.2010.239. Epub 2010 Sep 24. PMID:20871592 doi:http://dx.doi.org/10.1038/emboj.2010.239

8qfb, resolution 3.04Å

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OCA
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