8qfb

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Crystal structure of human MPP8 C-terminal region (residues 565-860)Crystal structure of human MPP8 C-terminal region (residues 565-860)

Structural highlights

8qfb is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.04Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MPP8_HUMAN Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression.[1]

References

  1. ↑ Kokura K, Sun L, Bedford MT, Fang J. Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion. EMBO J. 2010 Nov 3;29(21):3673-87. doi: 10.1038/emboj.2010.239. Epub 2010 Sep 24. PMID:20871592 doi:http://dx.doi.org/10.1038/emboj.2010.239

8qfb, resolution 3.04Å

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OCA
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