8pfb: Difference between revisions

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-'''Unreleased structure'''
-The entry 8pfb is ON HOLD  until Paper Publication
+==Structure of a heteropolymeric type 4 pilus from a monoderm bacterium==
+<StructureSection load='8pfb' size='340' side='right'caption='[[8pfb]], [[Resolution|resolution]] 3.67&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8pfb]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_sanguinis Streptococcus sanguinis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PFB FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.67&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pfb OCA], [https://pdbe.org/8pfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pfb RCSB], [https://www.ebi.ac.uk/pdbsum/8pfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pfb ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0A0B7GU52_STRSA A0A0B7GU52_STRSA]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Type 4 pili (T4P) are important virulence factors, which belong to a superfamily of nanomachines ubiquitous in prokaryotes, called type 4 filaments (T4F). T4F are defined as helical polymers of type 4 pilins. Recent advances in cryo-electron microscopy (cryo-EM) led to structures of several T4F, revealing that the long N-terminal alpha-helix (alpha1) - the trademark of pilins - packs in the centre of the filaments to form a hydrophobic core. In diderm bacteria - all available bacterial T4F structures are from diderm species - a portion of alpha1 is melted (unfolded). Here we report that this architecture is conserved in phylogenetically distant monoderm species by determining the structure of Streptococcus sanguinis T4P. Our 3.7 A resolution cryo-EM structure of S. sanguinis heteropolymeric T4P and the resulting full atomic model including all minor pilins highlight universal features of bacterial T4F and have widespread implications in understanding T4F biology.
-Authors: Anger, R., Pieulle, L., Shahin, M., Valette, O., Le Guenno, H., Kosta, A., Pelicic, V., Fronzes, R.
+Structure of a heteropolymeric type 4 pilus from a monoderm bacterium.,Anger R, Pieulle L, Shahin M, Valette O, Le Guenno H, Kosta A, Pelicic V, Fronzes R Nat Commun. 2023 Nov 6;14(1):7143. doi: 10.1038/s41467-023-42872-5. PMID:37932265<ref>PMID:37932265</ref>
-Description: Structure of a heteropolymeric type 4 pilus from a monoderm bacterium
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Fronzes, R]]
+<div class="pdbe-citations 8pfb" style="background-color:#fffaf0;"></div>
-[[Category: Kosta, A]]
+== References ==
-[[Category: Pelicic, V]]
+<references/>
-[[Category: Anger, R]]
+__TOC__
-[[Category: Pieulle, L]]
+</StructureSection>
-[[Category: Valette, O]]
+[[Category: Large Structures]]
-[[Category: Shahin, M]]
+[[Category: Streptococcus sanguinis]]
-[[Category: Le Guenno, H]]
+[[Category: Anger R]]
+[[Category: Fronzes R]]
+[[Category: Kosta A]]
+[[Category: Le Guenno H]]
+[[Category: Pelicic V]]
+[[Category: Pieulle L]]
+[[Category: Shahin M]]
+[[Category: Valette O]]