8pfb

Structure of a heteropolymeric type 4 pilus from a monoderm bacteriumStructure of a heteropolymeric type 4 pilus from a monoderm bacterium

Structural highlights 8pfb is a 9 chain structure with sequence from Streptococcus sanguinis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.67Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A0B7GU52_STRSA Publication Abstract from PubMed Type 4 pili (T4P) are important virulence factors, which belong to a superfamily of nanomachines ubiquitous in prokaryotes, called type 4 filaments (T4F). T4F are defined as helical polymers of type 4 pilins. Recent advances in cryo-electron microscopy (cryo-EM) led to structures of several T4F, revealing that the long N-terminal alpha-helix (alpha1) - the trademark of pilins - packs in the centre of the filaments to form a hydrophobic core. In diderm bacteria - all available bacterial T4F structures are from diderm species - a portion of alpha1 is melted (unfolded). Here we report that this architecture is conserved in phylogenetically distant monoderm species by determining the structure of Streptococcus sanguinis T4P. Our 3.7 A resolution cryo-EM structure of S. sanguinis heteropolymeric T4P and the resulting full atomic model including all minor pilins highlight universal features of bacterial T4F and have widespread implications in understanding T4F biology. Structure of a heteropolymeric type 4 pilus from a monoderm bacterium.,Anger R, Pieulle L, Shahin M, Valette O, Le Guenno H, Kosta A, Pelicic V, Fronzes R Nat Commun. 2023 Nov 6;14(1):7143. doi: 10.1038/s41467-023-42872-5. PMID:37932265 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

spinqualitylabelsall models 8pfb, resolution 3.67Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image