8b4d: Difference between revisions
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==ToxR bacterial transcriptional regulator bound to 40 bp toxT promoter DNA== | |||
<StructureSection load='8b4d' size='340' side='right'caption='[[8b4d]], [[Resolution|resolution]] 2.64Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8b4d]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B4D FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.64Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b4d OCA], [https://pdbe.org/8b4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b4d RCSB], [https://www.ebi.ac.uk/pdbsum/8b4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b4d ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TOXR_VIBCH TOXR_VIBCH] This transcription activator controls cholera toxin, pilus colonization factor and outer membrane protein expression in V.cholerae. It binds to the 5'-TTTTGAT-3' tandemly repeated DNA sequence in the cholera toxin promoter region. ToxS interacts with the C-terminal periplasmic domain of ToxR, stimulating its activity. It activates transcription at the promoters for tcpI and tcpA and this is presumably via ToxT. | |||
==See Also== | |||
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Vibrio cholerae]] | |||
[[Category: Canals A]] | |||
[[Category: Coll M]] | |||
[[Category: El Yaman N]] | |||
[[Category: Fabrega-Ferrer M]] | |||
[[Category: Krukonis ES]] | |||
[[Category: Muriel M]] | |||
[[Category: Perez-Luque R]] | |||
[[Category: Pieretti S]] | |||
Latest revision as of 09:26, 19 June 2024
ToxR bacterial transcriptional regulator bound to 40 bp toxT promoter DNAToxR bacterial transcriptional regulator bound to 40 bp toxT promoter DNA
Structural highlights
FunctionTOXR_VIBCH This transcription activator controls cholera toxin, pilus colonization factor and outer membrane protein expression in V.cholerae. It binds to the 5'-TTTTGAT-3' tandemly repeated DNA sequence in the cholera toxin promoter region. ToxS interacts with the C-terminal periplasmic domain of ToxR, stimulating its activity. It activates transcription at the promoters for tcpI and tcpA and this is presumably via ToxT. See Also |
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