7yh3: Difference between revisions
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==TRAPPC3 from Thorarchaeota SMTZ1-45== | |||
<StructureSection load='7yh3' size='340' side='right'caption='[[7yh3]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7yh3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Candidatus_Thorarchaeota_archaeon_SMTZ1-45 Candidatus Thorarchaeota archaeon SMTZ1-45]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YH3 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yh3 OCA], [https://pdbe.org/7yh3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yh3 RCSB], [https://www.ebi.ac.uk/pdbsum/7yh3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yh3 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A135VRB8_9ARCH A0A135VRB8_9ARCH] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Membrane-enclosed organelles are defining features of eukaryotes in distinguishing these organisms from prokaryotes. Specification of distinct membranes is critical to assemble and maintain discrete compartments. Small GTPases and their regulators are the signaling molecules that drive membrane-modifying machineries to the desired location. These signaling molecules include Rab and Rag GTPases, roadblock and longin domain proteins, and TRAPPC3-like proteins. Here, we take a structural approach to assess the relatedness of these eukaryotic-like proteins in Asgard archaea, the closest known prokaryotic relatives to eukaryotes. We find that the Asgard archaea GTPase core domains closely resemble eukaryotic Rabs and Rags. Asgard archaea roadblock, longin and TRAPPC3 domain-containing proteins form dimers similar to those found in the eukaryotic TRAPP and Ragulator complexes. We conclude that the emergence of these protein architectures predated eukaryogenesis, however further adaptations occurred in proto-eukaryotes to allow these proteins to regulate distinct internal membranes. | |||
The eukaryotic-like characteristics of small GTPase, roadblock and TRAPPC3 proteins from Asgard archaea.,Tran LT, Akil C, Senju Y, Robinson RC Commun Biol. 2024 Mar 12;7(1):273. doi: 10.1038/s42003-024-05888-1. PMID:38472392<ref>PMID:38472392</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 7yh3" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Candidatus Thorarchaeota archaeon SMTZ1-45]] | |||
[[Category: Large Structures]] | |||
[[Category: Robinson RC]] | |||
[[Category: Tran LT]] | |||
Latest revision as of 09:30, 29 January 2025
TRAPPC3 from Thorarchaeota SMTZ1-45TRAPPC3 from Thorarchaeota SMTZ1-45
Structural highlights
FunctionPublication Abstract from PubMedMembrane-enclosed organelles are defining features of eukaryotes in distinguishing these organisms from prokaryotes. Specification of distinct membranes is critical to assemble and maintain discrete compartments. Small GTPases and their regulators are the signaling molecules that drive membrane-modifying machineries to the desired location. These signaling molecules include Rab and Rag GTPases, roadblock and longin domain proteins, and TRAPPC3-like proteins. Here, we take a structural approach to assess the relatedness of these eukaryotic-like proteins in Asgard archaea, the closest known prokaryotic relatives to eukaryotes. We find that the Asgard archaea GTPase core domains closely resemble eukaryotic Rabs and Rags. Asgard archaea roadblock, longin and TRAPPC3 domain-containing proteins form dimers similar to those found in the eukaryotic TRAPP and Ragulator complexes. We conclude that the emergence of these protein architectures predated eukaryogenesis, however further adaptations occurred in proto-eukaryotes to allow these proteins to regulate distinct internal membranes. The eukaryotic-like characteristics of small GTPase, roadblock and TRAPPC3 proteins from Asgard archaea.,Tran LT, Akil C, Senju Y, Robinson RC Commun Biol. 2024 Mar 12;7(1):273. doi: 10.1038/s42003-024-05888-1. PMID:38472392[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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