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==Heterogeneous nuclear ribonucleoprotein H1, qRRM2 domain== | |||
<StructureSection load='7zug' size='340' side='right'caption='[[7zug]], [[Resolution|resolution]] 1.07Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7zug]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZUG FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.075Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zug OCA], [https://pdbe.org/7zug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zug RCSB], [https://www.ebi.ac.uk/pdbsum/7zug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zug ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/HNRH1_HUMAN HNRH1_HUMAN] Precursor T-cell acute lymphoblastic leukemia. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HNRH1_HUMAN HNRH1_HUMAN] This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).<ref>PMID:11003644</ref> <ref>PMID:16946708</ref> | |||
==See Also== | |||
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Isupov MN]] | |||
[[Category: Kumar M]] | |||
[[Category: Wiener R]] | |||
[[Category: Winter N]] | |||
Latest revision as of 09:23, 19 June 2024
Heterogeneous nuclear ribonucleoprotein H1, qRRM2 domainHeterogeneous nuclear ribonucleoprotein H1, qRRM2 domain
Structural highlights
DiseaseHNRH1_HUMAN Precursor T-cell acute lymphoblastic leukemia. FunctionHNRH1_HUMAN This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).[1] [2] See AlsoReferences
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