8d9y: Difference between revisions
Jump to navigation
Jump to search
New page: '''Unreleased structure''' The entry 8d9y is ON HOLD Authors: Pletnev, S., Verardi, R., Tully, E.S., Glanville, J., Kwong, P.D. Description: Crystal structure of Taipan alpha-neurotoxi... |
No edit summary |
||
| (3 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Crystal structure of Taipan alpha-neurotoxin in complex with Centi-LNX-D09 antibody== | |||
<StructureSection load='8d9y' size='340' side='right'caption='[[8d9y]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8d9y]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Oxyuranus_scutellatus_scutellatus Oxyuranus scutellatus scutellatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D9Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D9Y FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d9y OCA], [https://pdbe.org/8d9y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d9y RCSB], [https://www.ebi.ac.uk/pdbsum/8d9y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d9y ProSAT]</span></td></tr> | ||
[[Category: Glanville | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/3L21_OXYSC 3L21_OXYSC] Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.[UniProtKB:P60615] | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Oxyuranus scutellatus scutellatus]] | |||
[[Category: Glanville J]] | |||
[[Category: Kwong PD]] | |||
[[Category: Pletnev S]] | |||
[[Category: Tully ES]] | |||
[[Category: Verardi R]] | |||
Latest revision as of 08:52, 4 September 2024
Crystal structure of Taipan alpha-neurotoxin in complex with Centi-LNX-D09 antibodyCrystal structure of Taipan alpha-neurotoxin in complex with Centi-LNX-D09 antibody
Structural highlights
Function3L21_OXYSC Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.[UniProtKB:P60615] |
| ||||||||||||||||