3fe2: Difference between revisions

<table><tr><td colspan='2'>[[3fe2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FE2 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[https://www.uniprot.org/uniprot/DDX5_HUMAN DDX5_HUMAN] Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1.<ref>PMID:10409727</ref> <ref>PMID:11250900</ref> <ref>PMID:12527917</ref> <ref>PMID:15298701</ref> <ref>PMID:15660129</ref> <ref>PMID:17011493</ref> <ref>PMID:18829551</ref> <ref>PMID:17960593</ref> <ref>PMID:19718048</ref> <ref>PMID:21343338</ref>  

[[Category: Homo sapiens]]

[[Category: Arrowsmith CH]]

[[Category: Berglund H]]

[[Category: Bountra C]]

[[Category: Collins R]]

[[Category: Dahlgren LG]]

[[Category: Edwards AM]]

[[Category: Flodin S]]

[[Category: Flores A]]

[[Category: Graslund S]]

[[Category: Hammarstrom M]]

[[Category: Johansson A]]

[[Category: Johansson I]]

[[Category: Karlberg T]]

[[Category: Kotenyova T]]

[[Category: Lehtio L]]

[[Category: Moche M]]

[[Category: Nilsson ME]]

[[Category: Nordlund P]]

[[Category: Nyman T]]

[[Category: Persson C]]

[[Category: Sagemark J]]

[[Category: Schuler H]]

[[Category: Siponen MI]]

[[Category: Thorsell AG]]

[[Category: Tresaugues L]]

[[Category: Van Den Berg S]]

[[Category: Weigelt J]]

[[Category: Welin M]]

[[Category: Wikstrom M]]

[[Category: Wisniewska M]]