Ecotin: Difference between revisions

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**[[4iw4]] – ECO + mannan-binding lectin serine protease<br />
**[[4iw4]] – ECO + mannan-binding lectin serine protease<br />
**[[7cbk]] – ECO + elastase<br />
**[[7cbk]] – ECO + elastase<br />
**[[7pqo]] – ECO (mutant) + MASP-1<br />
**[[7pqn]] – ECO + MASP-2<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 12:53, 8 February 2023


Ecotin (ECO) is a serine protease inhibitor found in the periplasm of E. coli. It is a potent anti and a reversible tight-binding inhibitor of human factor Xa.[1]

with .

in thrombin heavy chain (1id5).[2] Water molecules shown as red spheres.

The dimeric E. coli ecotin (yellow) complex with thrombin heavy chain (cyan) and light chain (magenta) and Ca+2 ion (green) 1id5

Drag the structure with the mouse to rotate

3D Structures of Ecotin3D Structures of Ecotin

Updated on 08-February-2023

ReferencesReferences

  1. ↑ Eggers CT, Murray IA, Delmar VA, Day AG, Craik CS. The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase. Biochem J. 2004 Apr 1;379(Pt 1):107-18. PMID:14705961 doi:http://dx.doi.org/10.1042/BJ20031790
  2. ↑ Wang SX, Esmon CT, Fletterick RJ. Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions. Biochemistry. 2001 Aug 28;40(34):10038-46. PMID:11513582

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky
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