7bln: Difference between revisions

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New page: '''Unreleased structure''' The entry 7bln is ON HOLD Authors: Leneva, N., Kovtun, O., Morado, D.R., Briggs, J.A.G., Owen, D.J. Description: VPS35/VPS29 arch of metazoan membrane-assemb...
 
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'''Unreleased structure'''


The entry 7bln is ON HOLD
==VPS35/VPS29 arch of metazoan membrane-assembled retromer:SNX3 complex modelled with human proteins==
<StructureSection load='7bln' size='340' side='right'caption='[[7bln]], [[Resolution|resolution]] 8.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7bln]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BLN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BLN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bln OCA], [https://pdbe.org/7bln PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bln RCSB], [https://www.ebi.ac.uk/pdbsum/7bln PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bln ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VPS29_HUMAN VPS29_HUMAN] Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro).<ref>PMID:15247922</ref>


Authors: Leneva, N., Kovtun, O., Morado, D.R., Briggs, J.A.G., Owen, D.J.
==See Also==
 
*[[Vacuolar protein sorting-associated protein 3D structures|Vacuolar protein sorting-associated protein 3D structures]]
Description: VPS35/VPS29 arch of metazoan membrane-assembled retromer:SNX3 complex modelled with human proteins
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Morado, D.R]]
__TOC__
[[Category: Briggs, J.A.G]]
</StructureSection>
[[Category: Leneva, N]]
[[Category: Homo sapiens]]
[[Category: Kovtun, O]]
[[Category: Large Structures]]
[[Category: Owen, D.J]]
[[Category: Briggs JAG]]
[[Category: Kovtun O]]
[[Category: Leneva N]]
[[Category: Morado DR]]
[[Category: Owen DJ]]

Latest revision as of 10:48, 1 May 2024

VPS35/VPS29 arch of metazoan membrane-assembled retromer:SNX3 complex modelled with human proteinsVPS35/VPS29 arch of metazoan membrane-assembled retromer:SNX3 complex modelled with human proteins

Structural highlights

7bln is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 8.9Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

VPS29_HUMAN Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro).[1]

See Also

References

  1. ↑ Verges M, Luton F, Gruber C, Tiemann F, Reinders LG, Huang L, Burlingame AL, Haft CR, Mostov KE. The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor. Nat Cell Biol. 2004 Aug;6(8):763-9. Epub 2004 Jul 11. PMID:15247922 doi:10.1038/ncb1153

7bln, resolution 8.90Å

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