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==N-TERMINAL DOMAIN OF TFIIB, NMR==
==N-TERMINAL DOMAIN OF TFIIB, NMR==
<StructureSection load='1pft' size='340' side='right'caption='[[1pft]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
<StructureSection load='1pft' size='340' side='right'caption='[[1pft]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1pft]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43587 Atcc 43587]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PFT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1PFT FirstGlance]. <br>
<table><tr><td colspan='2'>[[1pft]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PFT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PYROCOCCUS FURIOSUS TFIIB GENE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1pft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pft OCA], [http://pdbe.org/1pft PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pft RCSB], [http://www.ebi.ac.uk/pdbsum/1pft PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pft ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pft OCA], [https://pdbe.org/1pft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pft RCSB], [https://www.ebi.ac.uk/pdbsum/1pft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pft ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TF2B_PYRFU TF2B_PYRFU]] Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).  
[https://www.uniprot.org/uniprot/TF2B_PYRFU TF2B_PYRFU] Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 20: Line 20:
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pft ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pft ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The three-dimensional structure of the N-terminal domain of an archaeal TFIIB, which has high sequence homology with eucaryal analogues, is strikingly similar to that of the C-terminal zinc ribbon of the eucaryal transcription elongation factor TFIIB.
The N-terminal domain of TFIIB from Pyrococcus furiosus forms a zinc ribbon.,Zhu W, Zeng Q, Colangelo CM, Lewis M, Summers MF, Scott RA Nat Struct Biol. 1996 Feb;3(2):122-4. PMID:8564536<ref>PMID:8564536</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1pft" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Transcription initiation factors 3D structures|Transcription initiation factors 3D structures]]
*[[Transcription initiation factors 3D structures|Transcription initiation factors 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 43587]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Colangelo, C M]]
[[Category: Pyrococcus furiosus]]
[[Category: Lewis, L M]]
[[Category: Colangelo CM]]
[[Category: Scott, R A]]
[[Category: Lewis LM]]
[[Category: Summers, M F]]
[[Category: Scott RA]]
[[Category: Zeng, Q]]
[[Category: Summers MF]]
[[Category: Zhu, W]]
[[Category: Zeng Q]]
[[Category: N-terminal domain]]
[[Category: Zhu W]]
[[Category: Tfiib]]
[[Category: Transcription initiation]]
[[Category: Transcription initiation factor]]

Latest revision as of 08:55, 17 April 2024

N-TERMINAL DOMAIN OF TFIIB, NMRN-TERMINAL DOMAIN OF TFIIB, NMR

Structural highlights

1pft is a 1 chain structure with sequence from Pyrococcus furiosus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TF2B_PYRFU Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

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OCA
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