SAGA-associated factor: Difference between revisions

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**[[2lo2]] – ySGF zinc finger domain – yeast – NMR<br />
**[[2lo2]] – ySGF zinc finger domain – yeast – NMR<br />
**[[3kik]], [[3kjl]] – ySGF Sus1-binding domain + Sus1 <br />
**[[3kik]], [[3kjl]] – ySGF Sus1-binding domain + Sus1 <br />
**[[3mhh]], [[3m99]], [[4fip]], [[4fjc]], [[4fk5]], [[4wa6]] – yUBP8 + Sus1 +SGF73 - yeast<br />
**[[3mhh]], [[3m99]], [[4fip]], [[4fjc]], [[4fk5]], [[4wa6]] – ySGF11 + SGF73 + yUBP8 + SUS1 <br />
**[[3mhs]] – yUBP8 + Sus1 +SGF73 + ubiquitin<br />
**[[3mhs]], [[6aqr]] – ySGF11 + SGF73 + yUBP8 + SUS1 + ubiquitin<br />
**[[4w4u]], [[6aqr]] – ySGF11 + SUS1+ SGF73 + ubiquitin carboxyl terminal hydrolase<br />
**[[4w4u]], [[6aqr]] – ySGF11 + ySGF73 + SUS1 + ubiquitin carboxyl terminal hydrolase<br />
**[[4zux]] – yUBP8 + SUS1 + SGF11 +SGF73 + ubiquitin + histone H3.2, H4, H2A, H2B + DNA<br />
**[[4zux]] – SGF11 + SGF73 + yUBP8 + SUS1 + ubiquitin + histone H3.2, H4, H2A, H2B + DNA<br />
**[[6tbm]] – KpSGF + TBP + SPT20 + SPT8 + transcription coactivator HFI1 + TFIID + polyubiquitin + SUS1 + transcription-associated protein – ''Komagataela phaffii'' - Cryo EM<br />


*SGF29
*SGF29
Line 29: Line 30:
*SGF73
*SGF73


**[[6t9i]], [[6t9k]], [[6t9l]] – ySGF in transcription coactivator SAGA – Cryo EM<br />
**[[2lo3]] – ySGF zinc finger domain – NMR<br />
**[[2lo3]] – ySGF zinc finger domain – NMR<br />
**[[3mhh]], [[3m99]], [[4fip]], [[4fjc]], [[4fk5]], [[4wa6]] – ySGF73 + yUBP8 + Sus1 <br />
**[[3mhs]] – ySGF73 + yUBP8 + Sus1 + ubiquitin<br />
**[[6tb4]] – KpSGF + TBP + SPT20 + transcription coactivator HFI1 + TFIID + ADA3 + transcription-associated protein - Cryo EM<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category: Topic Page]]
[[Category: Topic Page]]

Latest revision as of 14:05, 9 March 2022


SAGA-associated factor (SGF) is part of the coactivator complex SAGA (Spt-Ada-Gcn5-Acetyl transferase) which facilitates transcription of stress-activated genes[1].

  • SGF11 is required for the deubiuqitination of histone H2B and for the maintenance of steady-state H3 methylation level.
  • SGF29 binds methylated lysine of histone H3 and is involved in transcriptional regulation[2].
  • SGF73 is required for the assembly of RITS complex in yeast[3].
    .

Structure of SGF11 (pink) in the SAGA complex with Sus1 (green) , SGF73 (magenta), ubiquitin (yellow), UB8P (grey), glycerol and Zn+2 ions (grey) (PDB entry 3mhs)

Drag the structure with the mouse to rotate

3D structures of SAGA-associated factor3D structures of SAGA-associated factor

Updated on 09-March-2022

ReferencesReferences

  1. ↑ Mischerikow N, Spedale G, Altelaar AF, Timmers HT, Pijnappel WW, Heck AJ. In-depth profiling of post-translational modifications on the related transcription factor complexes TFIID and SAGA. J Proteome Res. 2009 Nov;8(11):5020-30. doi: 10.1021/pr900449e. PMID:19731963 doi:http://dx.doi.org/10.1021/pr900449e
  2. ↑ Schram AW, Baas R, Jansen PW, Riss A, Tora L, Vermeulen M, Timmers HT. A dual role for SAGA-associated factor 29 (SGF29) in ER stress survival by coordination of both histone H3 acetylation and histone H3 lysine-4 trimethylation. PLoS One. 2013 Jul 23;8(7):e70035. doi: 10.1371/journal.pone.0070035. Print 2013. PMID:23894581 doi:http://dx.doi.org/10.1371/journal.pone.0070035
  3. ↑ Deng X, Zhou H, Zhang G, Wang W, Mao L, Zhou X, Yu Y, Lu H. Sgf73, a subunit of SAGA complex, is required for the assembly of RITS complex in fission yeast. Sci Rep. 2015 Oct 7;5:14707. doi: 10.1038/srep14707. PMID:26443059 doi:http://dx.doi.org/10.1038/srep14707

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman
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