Lactoperoxidase

Function Lactoperoxidase (LPO) catalyzes the oxidation of thiocyanate, bromide and iodide using hydrogen peroxide. LPO is the second most abundant enzyme in milk. Heme is the cofactor of LPO. LPO contains a strongly-chelated calcium ion. Relevance The short-lived oxidized intermediates of the LPO reaction serve as potent bactericidal agents. LPO is used as an antimicrobial agent in milk and its products, in cosmetics, toothpaste and ophthalmic solutions. Structural highlights The . Water molecules shown as red spheres. .

spinqualitylabelsall models Glycosylated bovine lactoferrin containing heme complex with thiocyanate, I- (purple) and Ca+2 (green) ions (PDB entry 3eri) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of lactoperoxidase3D structures of lactoperoxidase

Updated on 26-March-2024

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• Lactoperoxidase binary complex
  • 2pt3 - bPLO + phosphate - bovine
    
  • 2nqx, 5b72 – bPLO + I
    
  • 7dlq – bPLO + H2O2
    
  • 2r5l – gLPO + I – goat
    
  • 3nak – gLPO + formate
    
  • 6ky7, 7c73, 7c74, 7c75, 7d52, 7dao, 7de5, 7dmr – yPLO + Ca - yak
    
  • 7c74 - yLPO + Cl
    
  • 6l32, 6l42, 7d52, 6l5g, 7c75 - yLPO + Zn
    
  • 6lqw, 7y3u – yPLO + H2O2
    
  • 7c73 – yPLO + phosphoserine
    
• Lactoperoxidase ternary complex
  • 2ips, 3eri, 3gc1, 6a4y, 6lco, 6m7e, 7dn7 – bLPO + SCN + I
    
  • 2qrb – bLPO + SCN + Cl
    
  • 3bxi – bLPO + SCN + nitrate
    
  • 4pnx - bPLO + bromomethane + I
    
  • 2pum – bPLO + catechol + I
    
  • 3krq – bLPO + amino-triazole + I
    
  • 6kmk – bPLO + H2O2 + phosphoserine
    
  • 7dlq, 7dn6 – bPLO + H2O2 + I
    
  • 2z5z – wbPLO + F + I – water buffalo
    
  • 2o86 – wbPLO + nitrate + I
    
  • 3erh - wbLPO + SCN + I
    
  • 7de5 - yLPO + SCN + I
    
  • 2ojv – gPLO + CN + I
    
  • 3n8f - gLPO + SCN + nitrate
    
  • 5ff1 - gLPO + methimazole + nitrate
    
  • 5hpw - gLPO + propyl-thiouracil + nitrate
    
  • 3niu – gLPO + diethylene glycol + phosphate
    
  • 3rke - gPLO + inhibitor + I
    
  • 2ikc – sLPO + carbonate + formate – sheep
    
  • 7ve3 - sLPO + hypoiodite + I
    
• Lactoperoxidase quaternary complex
  • 3gcj, 2qpk - bPLO + salicylhydroxamic acid + SCN + I
    
  • 3gck - bPLO + benzylhydroxamic acid + SCN + I
    
  • 3uba, 4gm7 - bPLO + hydroxycinnamic acid + SCN + I
    
  • 3gcl, 2qqt - bPLO + aspirin + SCN + I
    
  • 3i6n - bPLO + isoniazid + SCN + I
    
  • 4ksz - bPLO + cystein + SCN + I
    
  • 5wv3 - bPLO + oxidosulfanyl-methanamine + Br + I
    
  • 7dlq - bPLO + Br + Cl + SCN + I
    
  • 7wyj - bPLO + indomethacin + SCN + I
    
  • 3py4, 6m7e - bPLO + paracetamol + SCN + I
    
  • 7dn6 - bPLO + phenyliso-SCN + SCN + I
    
  • 7dn7 - bPLO + nitro-phenoxymethanesulfonanilide+ SCN + I
    
  • 8y9x, 4njb, 6lco - bPLO + pyridine derivative + SCN + I
    
  • 3r4x, 5zgs - bPLO + pyrazine derivative + SCN + I
    
  • 3r5o - bPLO + methoxyphenol + SCN + I
    
  • 3tgy - bPLO + ascorbate + SCN + I
    
  • 3v6q - bPLO + CO + SCN + I
    
  • 6l9t - bLPO + Zn + OSCN + I
    
  • 5gls - bLPO + butyl-triazole + SCN + I
    
  • 5gh0 - bLPO + mercaptoimidazole + nitrate + carbonate
    
  • 2gjm - wbPLO + carbonate + SCN + I
    
  • 3faq – wbLPO + CN + SCN + I
    
  • 3fnl - wbPLO + salicylhydroxamic acid + SCN + I
    
  • 4y55 - wbLPO + rhodanide + SCN + I
    
  • 2e9e – gPLO + nitrate + carbonate + SCN + CN
    
  • 2efb – gPLO + phosphate + carbonate + SCN + CN
    
  • 3qf1 - gPLO + piperazine + SCN + I
    
  • 8ing - gPLO + acrylonitrile + SCN + I
    
  • 4msf, 4oek - gPLO + phenol derivative+ SCN + I
    
  • 2eha – gPLO + formate + carbonate + SCN
    
  • 3r55, 6lf7 - gPLO + pyrazine derivative + SCN + I
    
  • 3sxv - gPLO + amitrole + SCN + I
    
  • 4qjq - gPLO + octopamine + SCN + I
    
  • 6lf7 - gPLO + hypocyanite + SCN + H2O2 + I
    
  • 7ve3 - sPLO +tetrahydrofuran + SCN + I
    
  • 6ky7, 6l2j – yPLO + H2O2 + phosphoserine + SCN + I