Phosphomannomutase: Difference between revisions

Latest revision as of 12:01, 28 August 2023

Function

Phosphomannomutase (PMM) catalyzes the conversion of α-D-mannose 1-phosphate to D-mannose 6-phosphate. PMM participates in fructose and mannose metabolism.

Disease

Mutations in PMM2 cause carbohydrate-deficient glycoprotein syndrome type 1 (Jaeken syndrome)^[1].

Structural highlights

The PMM structure contains a . It is known that in order for the substrate to bind, the cap must dissociate from the core domain and then re-associate to seal the active site from solvent molecules. The ^[2]. Water molecules are shown as red spheres.

Human phosphomannomutase 1 complex with α-D-mannose-1-phosphate and Mg+2 ion (green) (PDB entry 2fue)

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3D Structures of phosphomannomutase3D Structures of phosphomannomutase

Updated on 28-August-2023

ReferencesReferences

↑ Matthijs G, Schollen E, Pardon E, Veiga-Da-Cunha M, Jaeken J, Cassiman JJ, Van Schaftingen E. Mutations in PMM2, a phosphomannomutase gene on chromosome 16p13, in carbohydrate-deficient glycoprotein type I syndrome (Jaeken syndrome). Nat Genet. 1997 May;16(1):88-92. PMID:9140401 doi:10.1038/ng0597-88
↑ Silvaggi NR, Zhang C, Lu Z, Dai J, Dunaway-Mariano D, Allen KN. The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a. J Biol Chem. 2006 May 26;281(21):14918-26. Epub 2006 Mar 15. PMID:16540464 doi:http://dx.doi.org/10.1074/jbc.M601505200

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Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Matthijs G, Schollen E, Pardon E, Veiga-Da-Cunha M, Jaeken J, Cassiman JJ, Van Schaftingen E. Mutations in PMM2, a phosphomannomutase gene on chromosome 16p13, in carbohydrate-deficient glycoprotein type I syndrome (Jaeken syndrome). Nat Genet. 1997 May;16(1):88-92. PMID:9140401 doi:10.1038/ng0597-88

[2] Silvaggi NR, Zhang C, Lu Z, Dai J, Dunaway-Mariano D, Allen KN. The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a. J Biol Chem. 2006 May 26;281(21):14918-26. Epub 2006 Mar 15. PMID:16540464 doi:http://dx.doi.org/10.1074/jbc.M601505200

[1]

[2]

@@ Line 22: / Line 22: @@
 **[[6cfv]] – hPMM1 + Mg + inosine<br />
 **[[2fue]] – hPMM1 + α-D-mannose-1-phosphate + Mg<br />
+**[[7o0c]] – hPMM2 + Mg<br />
+**[[7o5z]] – hPMM2 (mutant) + Mg<br />
+**[[7o1b]], [[7o4g]], [[7o58]] – hPMM2 + α-D-glucose-1,6-bisphosphate + Mg<br />
 **[[2i54]] – LmPMM + Mg – ''Leishmania Mexicana''<br />
 **[[2i55]] - LmPMM + α-D-glucose-1,6-bisphosphate + Mg<br />
 **[[3f9r]] - PMM + Mg – ''Trypanosoma brucei''<br />
+**[[8b5v]] - PMM + Mg – ''Trypanosoma cruzi''<br />
 **[[6i5x]] – PMM + Mg – ''Aspergillus fumigata''<br />
 **[[1k35]] – PaPMM – ''Pseudomonas aeruginosa''<br />
@@ Line 32: / Line 36: @@
 **[[1pcj]], [[1pcm]] - PaPMM + α-D-mannose-1-phosphate<br />
 **[[5ue7]] - PMM – ''Candida albicans''<br />
+**[[7myv]] – PMM + Mg – ''Plasmodium falciparum''<br />
 *Phosphomannomutase/Phosphoglucomutase complex