Phosphomannomutase

Function Phosphomannomutase (PMM) catalyzes the conversion of α-D-mannose 1-phosphate to D-mannose 6-phosphate. PMM participates in fructose and mannose metabolism. Disease Mutations in PMM2 cause carbohydrate-deficient glycoprotein syndrome type 1 (Jaeken syndrome). Structural highlights The PMM structure contains a . It is known that in order for the substrate to bind, the cap must dissociate from the core domain and then re-associate to seal the active site from solvent molecules. The . Water molecules are shown as red spheres.

spinqualitylabelsall models Human phosphomannomutase 1 complex with α-D-mannose-1-phosphate and Mg+2 ion (green) (PDB entry 2fue) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of phosphomannomutase3D Structures of phosphomannomutase

Updated on 28-August-2023

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• Phosphomannomutase
  • 2amy, 2q4r – hPMM2 – human
    
  • 2fuc – hPMM1 + Mg
    
  • 6cfr, 6cfs, 6cft, 6cfu – hPMM1 (mutant) + Mg
    
  • 6cfv – hPMM1 + Mg + inosine
    
  • 2fue – hPMM1 + α-D-mannose-1-phosphate + Mg
    
  • 7o0c – hPMM2 + Mg
    
  • 7o5z – hPMM2 (mutant) + Mg
    
  • 7o1b, 7o4g, 7o58 – hPMM2 + α-D-glucose-1,6-bisphosphate + Mg
    
  • 2i54 – LmPMM + Mg – Leishmania Mexicana
    
  • 2i55 - LmPMM + α-D-glucose-1,6-bisphosphate + Mg
    
  • 3f9r - PMM + Mg – Trypanosoma brucei
    
  • 8b5v - PMM + Mg – Trypanosoma cruzi
    
  • 6i5x – PMM + Mg – Aspergillus fumigata
    
  • 1k35 – PaPMM – Pseudomonas aeruginosa
    
  • 1k2y – PaPMM (mutant)
    
  • 1p5d, 1p5g – PaPMM + α-D-glucose-1-phosphate
    
  • 4hjh - PaPMM + D-glucose-6-phosphate
    
  • 1pcj, 1pcm - PaPMM + α-D-mannose-1-phosphate
    
  • 5ue7 - PMM – Candida albicans
    
  • 7myv – PMM + Mg – Plasmodium falciparum
    
• Phosphomannomutase/Phosphoglucomutase complex
  • 1wqa – PMM/PGM + Mg – Pyrococcus horikoshii
    
  • 2fkf - PaPMM/PGM + α-D-glucose-1,6-bisphosphate
    
  • 2fkm - PaPMM/PGM (mutant) + α-D-glucose-1,6-bisphosphate
    
  • 3bkq - PaPMM/PGM (mutant) + α-D-glucose-1-phosphate
    
  • 4mrq - PaPMM/PGM
    
  • 3c04, 3rsm, 4il8 - PaPMM/PGM (mutant)
    
  • 2h4l - PaPMM/PGM + ribose-1-phosphate
    
  • 2h5a - PaPMM/PGM + xylose-1-phosphate
    
  • 2f7l - PMM/PGM – Sulfolobus tokodaii
    
  • 3uw2 – PMM/PGM PGM domain + phosphate – Burkholderia thailandensis
    
  • 6mnv – XcPMM/PGM + Mg + CH2FG1P – Xanthomonas citri
    
  • 6n1e – XcPMM/PGM + Mg + methyl-glucose-6-phosphate