Tumor necrosis factor: Difference between revisions
No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
(3 intermediate revisions by the same user not shown) | |||
Line 8: | Line 8: | ||
== Structural highlights == | == Structural highlights == | ||
The biological assembly of human tumor necrosis factor is <scene name='55/551212/Cv/4'>homotetramer</scene> (PDB entry [[2az5]]). <scene name='55/551212/Cv/5'>Inhibitor binding site</scene>. | The biological assembly of human tumor necrosis factor is <scene name='55/551212/Cv/4'>homotetramer</scene> (PDB entry [[2az5]]). <scene name='55/551212/Cv/5'>Inhibitor binding site</scene>. | ||
== 3D Structures of tumor necrosis factor == | == 3D Structures of tumor necrosis factor == | ||
[[Tumor necrosis factor 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
</StructureSection> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] |
Latest revision as of 14:08, 5 February 2024
FunctionTumor necrosis factor (TNF) is a cytokine which can cause apoptosis. TNFα is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells[1]. TNFβ is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see A Disintegrin And Metalloproteinase). See also TRAIL and Molecular Playground/TRAIL. RelevanceTNF is studied as both a target and a therapeutic in malignant diseases[2]. Structural highlightsThe biological assembly of human tumor necrosis factor is (PDB entry 2az5). .
3D Structures of tumor necrosis factorTumor necrosis factor 3D structures References
|
|