5tp1: Difference between revisions

<table><tr><td colspan='2'>[[5tp1]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydia_trachomatis_D/UW-3/CX Chlamydia trachomatis D/UW-3/CX] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TP1 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tp1 OCA], [https://pdbe.org/5tp1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tp1 RCSB], [https://www.ebi.ac.uk/pdbsum/5tp1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tp1 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/SNX5_MOUSE SNX5_MOUSE] Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol lipids. Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde transport of lysosomal enzyme receptor IGF2R. May function as link between endosomal transport vesicles and dynactin. Plays a role in the internalization of EGFR after EGF stimulation. Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C and is retromer-independent. Together with PIP5K1C facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C-mediated E-cadherin degradation (By similarity). Plays a role in macropinocytosis (PubMed:18854019).[UniProtKB:Q9Y5X3]<ref>PMID:18854019</ref>  

*[[Sorting nexin 3D structures|Sorting nexin 3D structures]]

[[Category: Mus musculus]]

[[Category: Czudnochowski N]]

[[Category: Rosenberg O]]