Cyclin-dependent kinase regulatory subunit: Difference between revisions
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== Function == | == Function == | ||
'''Cyclin-dependent kinase regulatory subunit''' (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex. CKS binds to the catalytic subunit of CDK see complex structure in <scene name='71/715441/Pdb4yc6/1'>pdb 4yc6</scene> where CDK1 is in grey, pink, magenta and gold and CKS1 i in green, yellow, cyan and red. CKS1 is essential for CDK5 functioning in neuronal differentiation.<ref>PMID:8491379</ref> | '''Cyclin-dependent kinase regulatory subunit''' (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex. CKS binds to the catalytic subunit of CDK see complex structure in <scene name='71/715441/Pdb4yc6/1'>pdb 4yc6</scene> where CDK1 is in grey, pink, magenta and gold and CKS1 i in green, yellow, cyan and red. | ||
*'''CKS1''' is essential for CDK5 functioning in neuronal differentiation.<ref>PMID:8491379</ref> | |||
*'''CKS2''' is implicated as an oncogene in various malignancies.<ref>PMID:31781310</ref> | |||
== Structural highlights == | == Structural highlights == | ||