Syntaxin-binding protein: Difference between revisions
No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (5 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load='3puj' size='340' side='right' caption='Rat syntaxin-binding protein 1 (green) complex with syntaxin-1 N-terminal peptide ( | <StructureSection load='3puj' size='340' side='right' caption='Rat syntaxin-binding protein 1 (green) complex with syntaxin-1 N-terminal peptide (magenta) (PDB code [[3puj]])' scene='80/803232/Cv/1'> | ||
== Function == | == Function == | ||
| Line 7: | Line 7: | ||
== Structural highlights == | == Structural highlights == | ||
Syntaxin-binding protein 1 interaction with the N-terminal peptide of syntaxin-1 which forms part of the SNARE complex shows the peptide forming a tight loop with numerous intermolecular hydrogen bonds. | <scene name='80/803232/Cv/4'>Syntaxin-binding protein 1 interaction with the N-terminal peptide of syntaxin-1</scene> which forms part of the SNARE complex shows the peptide forming a tight loop with numerous intermolecular hydrogen bonds. The STXBP1 and the syntaxin peptide interact via numerous electrostatic and polar interactions<ref name="stxbp"/>. | ||
</StructureSection> | </StructureSection> | ||
| Line 18: | Line 18: | ||
*Syntaxin-binding protein 1 or Munc18-1 | *Syntaxin-binding protein 1 or Munc18-1 | ||
**[[4jeh]], [[4jeu]], [[3c98]] – rSTXBP1 + | **[[6lpc]] – rSTXBP1 (mutant) – rat<br /> | ||
**[[4jeh]], [[4jeu]], [[3c98]] – rSTXBP1 + STX-1a<br /> | |||
**[[7udb]], [[7udc]] – rSTXBP1 + synaptobrevin-2 + STX-1a – Cryo EM<br /> | |||
**[[3puj]] – rSTXBP1 + syntaxin 4 peptide <br /> | **[[3puj]] – rSTXBP1 + syntaxin 4 peptide <br /> | ||
**[[7xsj]] – rSTXBP1 + Syntaxin 1a N-terminal+SNARE motif + amyloid-beta A4<br /> | |||
*Syntaxin-binding protein 2 or Munc18-2 | *Syntaxin-binding protein 2 or Munc18-2 | ||