Syntaxin-binding protein

Function Syntaxin-binding proteins (STXBP) are involved in the regulation of synaptic vesicle docking and fusion. STXBP1 participates in synaptic vesicle fusion via dual roles: as a docking/chaperone protein by binding Syntaxin-1 and as a fusion protein that binds SNARE complexes in a Syntaxin-1 N-peptide-dependent manner. STXBP2 binds SNARE proteins. Structural highlights which forms part of the SNARE complex shows the peptide forming a tight loop with numerous intermolecular hydrogen bonds. The STXBP1 and the syntaxin peptide interact via numerous electrostatic and polar interactions.

spinqualitylabelsall models Rat syntaxin-binding protein 1 (green) complex with syntaxin-1 N-terminal peptide (magenta) (PDB code 3puj) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of syntaxin-binding protein3D structures of syntaxin-binding protein

Updated on 11-December-2023

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• Syntaxin-binding protein 1 or Munc18-1
  • 6lpc – rSTXBP1 (mutant) – rat
    
  • 4jeh, 4jeu, 3c98 – rSTXBP1 + STX-1a
    
  • 7udb, 7udc – rSTXBP1 + synaptobrevin-2 + STX-1a – Cryo EM
    
  • 3puj – rSTXBP1 + syntaxin 4 peptide
    
  • 7xsj – rSTXBP1 + Syntaxin 1a N-terminal+SNARE motif + amyloid-beta A4
    
• Syntaxin-binding protein 2 or Munc18-2
  • 4cca – hSTXBP2 – human
    
• Syntaxin-binding protein 3 or Munc18-3
  • 3puk – rSTXBP3 + syntaxin 4 peptide
    
• Syntaxin-binding protein 4
  • 1wi4 – mSTXBP4 PDZ domain – mouse - NMR
    
  • 2ysg – mSTXBP4 WW domain - NMR