Trehalulose synthase: Difference between revisions
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== Function == | == Function == | ||
'''Trehalulose synthase''' (THS) converts sucrose to trehalulose (TH)<ref>PMID:7878741</ref>. | '''Trehalulose synthase''' or '''sucrose isomerase''' (THS) converts sucrose to trehalulose (TH)<ref>PMID:7878741</ref>. | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
<scene name='59/597011/Cv/ | <scene name='59/597011/Cv/5'>THS binds sucrose</scene> (water molecules are shown as red spheres) in a <scene name='59/597011/Cv/6'>deep pocket</scene> with mostly conserved residues<ref>PMID:17597061</ref>. | ||
</StructureSection> | </StructureSection> | ||
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**[[4go9]], [[4go8]] – PmTHS (mutant) <br /> | **[[4go9]], [[4go8]] – PmTHS (mutant) <br /> | ||
**[[4h2c]], [[4h8h]] – RhTHS (mutant) - ''Rhizobium''<br /> | **[[4h2c]], [[4h8h]] – RhTHS (mutant) - ''Rhizobium''<br /> | ||
**[[3gbd]] – PrTHS – ''Protaminobacter rubrum''<br /> | |||
**[[4how]] – ErTHS – ''Erwinia rhapontici''<br /> | |||
*Trehalulose synthase complex | *Trehalulose synthase complex | ||
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**[[2pwe]] – PmTHS (mutant) + sucrose<br /> | **[[2pwe]] – PmTHS (mutant) + sucrose<br /> | ||
**[[2pwf]] – PmTHS (mutant) + glucose<br /> | **[[2pwf]] – PmTHS (mutant) + glucose<br /> | ||
**[[4hoz]] – ErTHS + glucose<br /> | |||
**[[4hph]] – ErTHS + sucrose<br /> | |||
**[[4gi6]], [[4h7v]] – RhTHS (mutant) + glucose <br /> | **[[4gi6]], [[4h7v]] – RhTHS (mutant) + glucose <br /> | ||
**[[4gi8]] – RhTHS (mutant) + sucrose<br /> | **[[4gi8]] – RhTHS (mutant) + sucrose<br /> | ||
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**[[4gia]], [[4ha1]] – RhTHS (mutant) + isomaltulose<br /> | **[[4gia]], [[4ha1]] – RhTHS (mutant) + isomaltulose<br /> | ||
**[[4gin]] – RhTHS (mutant) + inhibitor<br /> | **[[4gin]] – RhTHS (mutant) + inhibitor<br /> | ||
**[[3gbe]] – PrTHS + inhibitor<br /> | |||
}} | }} | ||
Latest revision as of 14:17, 16 December 2020
FunctionTrehalulose synthase or sucrose isomerase (THS) converts sucrose to trehalulose (TH)[1]. RelevanceSince TH is a sugar substitute and is absorbed more slowly than sucrose it can be used in diabetic and sports food and drinks[2]. Structural highlights(water molecules are shown as red spheres) in a with mostly conserved residues[3]. |
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3D structures of trehalulose synthase3D structures of trehalulose synthase
Updated on 16-December-2020
ReferencesReferences
- ↑ Thevelein JM, Hohmann S. Trehalose synthase: guard to the gate of glycolysis in yeast? Trends Biochem Sci. 1995 Jan;20(1):3-10. PMID:7878741
- ↑ Venables MC, Brouns F, Jeukendrup AE. Oxidation of maltose and trehalose during prolonged moderate-intensity exercise. Med Sci Sports Exerc. 2008 Sep;40(9):1653-9. doi: 10.1249/MSS.0b013e318175716c. PMID:18685525 doi:http://dx.doi.org/10.1249/MSS.0b013e318175716c
- ↑ Ravaud S, Robert X, Watzlawick H, Haser R, Mattes R, Aghajari N. Trehalulose synthase native and carbohydrate complexed structures provide insights into sucrose isomerization. J Biol Chem. 2007 Sep 21;282(38):28126-36. Epub 2007 Jun 27. PMID:17597061 doi:10.1074/jbc.M704515200