Succinate-semialdehyde dehydrogenase: Difference between revisions
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== Function == | == Function == | ||
'''Succinate-semialdehyde dehydrogenase''' (SSD) catalyzes the conversion of succinate semialdehyde, NAD+ and water to succinate, NADH and H+. SSD participates in glutamate and butyrate metabolism<ref>PMID:13654295</ref>. | '''Succinate-semialdehyde dehydrogenase''' or '''α-ketoglutaric semialdehyde dehydrogenase''' or '''succinyl-CoA reductase''' (SSD) catalyzes the conversion of succinate semialdehyde, NAD+ and water to succinate, NADH and H+. SSD participates in glutamate and butyrate metabolism<ref>PMID:13654295</ref>. See also [[Aldehyde dehydrogenase]]. | ||
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
The active site of SSD contains the <scene name='59/590825/Cv/4'>substrate succinate semialdehyde</scene> and the <scene name='59/590825/Cv/ | The active site of SSD contains the <scene name='59/590825/Cv/4'>substrate succinate semialdehyde</scene> and the <scene name='59/590825/Cv/11'>cofactor NADP</scene><ref>PMID:23500184</ref>. Water molecules are shown as red spheres. <scene name='59/590825/Cv/12'>Whole binding site</scene>. | ||
</StructureSection> | </StructureSection> | ||
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*Succinate-semialdehyde dehydrogenase | *Succinate-semialdehyde dehydrogenase | ||
**[[2w8n]], [[2w8o]] – hSSD - human <br /> | |||
**[[2w8p]] – hSSD (mutant) <br /> | |||
**[[4it9]], [[3vz1]] – SySSD - ''Synechococcus''<br /> | **[[4it9]], [[3vz1]] – SySSD - ''Synechococcus''<br /> | ||
**[[3vz2]] – SySSD (mutant) <br /> | **[[3vz2]] – SySSD (mutant) <br /> | ||
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**[[5vbf]] – SSD – ''Burkholderia vietnamiensis''<br /> | **[[5vbf]] – SSD – ''Burkholderia vietnamiensis''<br /> | ||
**[[3rh9]] – SSD – ''Marinobacter aquaeolei''<br /> | **[[3rh9]] – SSD – ''Marinobacter aquaeolei''<br /> | ||
**[[4ogd]] – SpSSD – ''Streptococcus pyogenes'' <br /> | **[[4ogd]] – SpSSD – ''Streptococcus pyogenes'' <br /> | ||
**[[5x5t]] – AbSSD – ''Azuspirillum brasilense'' <br /> | |||
*Succinate-semialdehyde dehydrogenase complexes | *Succinate-semialdehyde dehydrogenase complexes | ||
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**[[4oht]] – SpSSD + NADPH<br /> | **[[4oht]] – SpSSD + NADPH<br /> | ||
**[[4ywu]], [[4ywv]] – SySSD + oxobutanoic acid + succinic semialdehyde<br /> | **[[4ywu]], [[4ywv]] – SySSD + oxobutanoic acid + succinic semialdehyde<br /> | ||
**[[5x5u]] – AbSSD + NAD<br /> | |||
**[[8c54]] – SSD + NADH – ''Rhizobium leguminosarum'' – Cryo EM<br /> | |||
**[[8cej]] – CkSSD + mesaconyl-c1-CoA – ''Clostridium kluyveri''<br /> | |||
**[[8cek]] – CkSSD + NADPH<br /> | |||
}} | }} | ||
Latest revision as of 12:49, 6 December 2023
FunctionSuccinate-semialdehyde dehydrogenase or α-ketoglutaric semialdehyde dehydrogenase or succinyl-CoA reductase (SSD) catalyzes the conversion of succinate semialdehyde, NAD+ and water to succinate, NADH and H+. SSD participates in glutamate and butyrate metabolism[1]. See also Aldehyde dehydrogenase.
DiseaseSSD deficiency is a disorder of GABA metabolism with symptoms of seizures, delayed development and hypotonia[2]. Structural highlightsThe active site of SSD contains the and the [3]. Water molecules are shown as red spheres. .
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3D structures of succinate-semialdehyde dehydrogenase3D structures of succinate-semialdehyde dehydrogenase
Updated on 06-December-2023
ReferencesReferences
- ↑ JAKOBY WB, SCOTT EM. Aldehyde oxidation. III. Succinic semialdehyde dehydrogenase. J Biol Chem. 1959 Apr;234(4):937-40. PMID:13654295
- ↑ Gordon N. Succinic semialdehyde dehydrogenase deficiency (SSADH) (4-hydroxybutyric aciduria, gamma-hydroxybutyric aciduria). Eur J Paediatr Neurol. 2004;8(5):261-5. PMID:15341910 doi:http://dx.doi.org/10.1016/j.ejpn.2004.06.004
- ↑ Yuan Z, Yin B, Wei D, Yuan YR. Structural basis for cofactor and substrate selection by cyanobacterium succinic semialdehyde dehydrogenase. J Struct Biol. 2013 May;182(2):125-35. doi: 10.1016/j.jsb.2013.03.001. Epub 2013 , Mar 13. PMID:23500184 doi:10.1016/j.jsb.2013.03.001