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[[Image:2pkt.jpg|left|200px]]


{{Structure
==Crystal structure of the human CLP-36 (PDLIM1) bound to the C-terminal peptide of human alpha-actinin-1==
|PDB= 2pkt |SIZE=350|CAPTION= <scene name='initialview01'>2pkt</scene>, resolution 1.500&Aring;
<StructureSection load='2pkt' size='340' side='right'caption='[[2pkt]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>
<table><tr><td colspan='2'>[[2pkt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PKT FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
|GENE= PDLIM1, CLIM1, CLP36 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pkt OCA], [https://pdbe.org/2pkt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pkt RCSB], [https://www.ebi.ac.uk/pdbsum/2pkt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pkt ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pkt OCA], [http://www.ebi.ac.uk/pdbsum/2pkt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pkt RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/PDLI1_HUMAN PDLI1_HUMAN] Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pk/2pkt_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pkt ConSurf].
<div style="clear:both"></div>


'''Crystal structure of the human CLP-36 (PDLIM1) bound to the C-terminal peptide of human alpha-actinin-1'''
==See Also==
 
*[[PDZ and LIM domain protein|PDZ and LIM domain protein]]
 
__TOC__
==About this Structure==
</StructureSection>
2PKT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PKT OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith CH]]
[[Category: Bray, J.]]
[[Category: Bray J]]
[[Category: Bunkoczi, G.]]
[[Category: Bunkoczi G]]
[[Category: Burgess-Brown, N.]]
[[Category: Burgess-Brown N]]
[[Category: Delft, F von.]]
[[Category: Doyle DA]]
[[Category: Doyle, D A.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Elkins J]]
[[Category: Elkins, J.]]
[[Category: Gileadi C]]
[[Category: Gileadi, C.]]
[[Category: Gileadi O]]
[[Category: Gileadi, O.]]
[[Category: Salah E]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Sundstrom M]]
[[Category: Salah, E.]]
[[Category: Ugochukwu E]]
[[Category: Sundstrom, M.]]
[[Category: Umeano C]]
[[Category: Ugochukwu, E.]]
[[Category: Uppenberg J]]
[[Category: Umeano, C.]]
[[Category: Weigelt J]]
[[Category: Uppenberg, J.]]
[[Category: Von Delft F]]
[[Category: Weigelt, J.]]
[[Category: pdz domain]]
[[Category: sgc]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:37:15 2008''

Latest revision as of 12:10, 21 February 2024

Crystal structure of the human CLP-36 (PDLIM1) bound to the C-terminal peptide of human alpha-actinin-1Crystal structure of the human CLP-36 (PDLIM1) bound to the C-terminal peptide of human alpha-actinin-1

Structural highlights

2pkt is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.5Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PDLI1_HUMAN Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2pkt, resolution 1.50Å

Drag the structure with the mouse to rotate

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OCA
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