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| == Structural highlights == | | == Structural highlights == |
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| AdK consists of a <scene name='57/573962/Cv/4'>large α/β domain with 9 β strands and 8 α helices and a small capping α/β domain with 5 β strands and 2 α helices</scene>. The <scene name='57/573962/Cv/3'>active site</scene> is formed along the edge of the β sheet in the large domain (PDB entry [[1bx4]]).<ref>PMID:9843365</ref> | | AdK consists of a <scene name='57/573962/Cv/4'>large α/β domain with 9 β strands and 8 α helices and a small capping α/β domain with 5 β strands and 2 α helices</scene> (PDB entry [[1bx4]]).<ref>PMID:9843365</ref> |
| </StructureSection> | | *<scene name='57/573962/Cv/6'>1st adenosine binding site</scene>. Water molecules are shown as red spheres. |
| | *<scene name='57/573962/Cv/7'>Cl coordination site</scene>. |
| | *<scene name='57/573962/Cv/8'>Cl/Mg cluster coordination site</scene>. |
| | *<scene name='57/573962/Cv/11'>2nd adenosine binding site</scene>. |
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| ==3D structures of adenosine kinase== | | ==3D structures of adenosine kinase== |
| | [[Adenosine kinase 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Adenosine kinase
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| **[[1lio]] – TgAdK – ''Toxoplasma gondii''<br />
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| **[[2pkf]] – MtAdK – ''Mycobacterium tuberculosis''<br />
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| **[[4n08]] – TbAdK – ''Trypanosoma brucei''<br />
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| *Adenosine kinase binary complex
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| **[[1bx4]] – hAdK + adenosine - human<br />
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| **[[2i6a]], [[2i6b]] – hAdK + prodrug <br />
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| **[[4o1l]] – hAdK + inhibitor <br />
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| **[[1dgm]], [[1lik]] – TgAdK + adenosine <br />
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| **[[2a9y]] – TgAdK (mutant) + dimethyladenosine <br />
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| **[[2abs]] – TgAdK (mutant) + AMP-PCP<br />
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| **[[2aa0]] – TgAdK (mutant) + methylthiopurine <br />
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| **[[2pkk]], [[4ube]] – MtAdK + fluoroadenosine <br />
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| **[[2pkn]] – MtAdK + AMP-PCP<br />
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| **[[2pkm]] – MtAdK + adenosine <br />
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| **[[4o1g]] – MtAdK + γ-thio-ATP <br />
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| **[[4pvv]] – MtAdK + inhibitor <br />
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| **[[5kb6]] – mAdK + adenosine - mouse<br />
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| **[[3loo]] – AdK + adenosine tetraphosphate – ''Anopheles gambiae''<br />
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| **[[2xtb]] – TbAdK + morpholine <br />
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| *Adenosine kinase ternary complex
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| **[[1lii]] – TgAdK + adenosine + AMP-PCP<br />
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| **[[2a9z]] – TgAdK (mutant) + dimethyladenosine + AMP-PCP<br />
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| **[[1lij]] – TgAdK + prodrug + AMP-PCP<br />
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| **[[2ab8]] – TgAdK (mutant) + methylthiopurine + AMP-PCP<br />
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| **[[3ubo]] – AdK + adenosine + ADP – ''Sinorhizobium meliloti''<br />
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| **[[4dc3]] – AdK + adenosine + fluoroadenosine – ''Schistosoma masoni''<br />
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| **[[4n09]] – TbAdK + adenosine + ADP <br />
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| **[[5kb5]] – mAdK + adenosine + ADP<br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |