Syntrophin: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

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+<StructureSection load='1qav' size='350' side='right' caption='Mouse syntrophin PDZ domain (deepskyblue) complex with neuronal NOS (green) (PDB code [[1qav]])' scene='77/777075/Cv/1'>
-<StructureSection load='1qav' size='340' side='right' caption='Mouse syntrophin PDZ domain (grey) complex with neuronal NOS (green) (PDB code [[1qav]])' scene=''>
+__TOC__
 == Function ==
-Syntrophins (Syn) are a family of membrane-associated adaptor proteins which are important components of many signaling events: regulating the postsynaptic signal transduction, sarcolemmal localization of brain NOS and G-protein mediated signaling <ref>PMID:23263165</ref>.
+'''Syntrophins''' (Syn) are a family of membrane-associated adaptor proteins which are important components of many signaling events: regulating the postsynaptic signal transduction, sarcolemmal localization of brain NOS and G-protein mediated signaling <ref>PMID:23263165</ref>.
+*'''alpha-1-syntrophin''' is a cytoskeletal protein interacting with cardiac sodium channel<ref>PMID:19684871</ref>.
+*'''beta-1-syntrophin''' is a scaffold protein that provides a platform for the formation of signal transduction complexes<ref>PMID:34277816</ref>.
 == Disease ==
 Mutations in Syn which interacts with sodium channel cause the inherited disorder long-QT syndrome resulting in sudden cardiac death<ref>PMID:19684871</ref>.
-== Relevance ==
 == Structural highlights ==
-Syn is characterized by a plekstrin homology domain(PH) which is split by a PDZ domain and a C-terminal Syn unique domain.  Syn binds the neuronal NOS β-finger via its binding groove<ref>PMID:10221915</ref>.
+Syn is characterized by a plekstrin homology domain(PH) which is split by a PDZ domain and a C-terminal Syn unique domain.  <scene name='77/777075/Cv/3'>Syn binds the neuronal NOS</scene> β-finger via its binding groove<ref>PMID:10221915</ref>.
-</StructureSection>
 == 3D Structures of syntrophin ==
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 {{#tree:id=OrganizedByTopic|openlevels=0|
-*α-1-syntrophin
+*alpha-1-syntrophin
 **[[1z86]] – mSyn PDZ domain – mouse - NMR  <br />
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 **[[2pdz]] – mSyn PDZ domain + voltage-gated sodium channel peptide - NMR  <br />
-*β-2-syntrophin
+*beta-1-syntrophin
+**[[7pc4]] – hSyn PDZ domain 107-196 + TAX-1 peptide  - human<br />
+**[[7p70]] – hSyn PDZ domain + HPV35-E6 peptide  <br />
+*beta-2-syntrophin
+**[[2vrf]] – hSyn PDZ domain  <br />
+*gamma-1-syntrophin
+**[[7qqn]] – hSyn PDZ domain 54-143 + TRPV3 peptide  <br />
+**[[7pc7]] – hSyn PDZ domain + PTEN peptide  <br />
+**[[7pc8]] – hSyn PDZ domain + RSK1 peptide  <br />
+*gamma-2-syntrophin
+**[[7qql]] – hSyn PDZ domain 70-159 + RSK1 peptide  <br />
-**[[2vrf]] – Syn PDZ domain – human  <br />
 }}
 == References ==
 <references/>
+</StructureSection>
 [[Category:Topic Page]]