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[[Image:2cfx.gif|left|200px]]


{{Structure
==Structure of B.subtilis LrpC==
|PDB= 2cfx |SIZE=350|CAPTION= <scene name='initialview01'>2cfx</scene>, resolution 2.40&Aring;
<StructureSection load='2cfx' size='340' side='right'caption='[[2cfx]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2cfx]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CFX FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfx OCA], [https://pdbe.org/2cfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cfx RCSB], [https://www.ebi.ac.uk/pdbsum/2cfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cfx ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfx OCA], [http://www.ebi.ac.uk/pdbsum/2cfx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cfx RCSB]</span>
[https://www.uniprot.org/uniprot/LRPC_BACSU LRPC_BACSU] Transcriptional regulator with a possible role in regulation of amino acid metabolism. Plays a role in the growth phase transition.
}}
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/2cfx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cfx ConSurf].
<div style="clear:both"></div>


'''STRUCTURE OF B.SUBTILIS LRPC'''
==See Also==
 
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
The Lrp/AsnC family of transcriptional regulatory proteins is found in both archaea and bacteria. Members of the family influence cellular metabolism in both a global (Lrp) and specific (AsnC) manner, often in response to exogenous amino acid effectors. In the present study we have determined both the first bacterial and the highest resolution structures for members of the family. Escherichia coli AsnC is a specific gene regulator whose activity is triggered by asparagine binding. Bacillus subtilis LrpC is a global regulator involved in chromosome condensation. Our AsnC-asparagine structure is the first for a regulator-effector complex and is revealed as an octameric disc. Key ligand recognition residues are identified together with a route for ligand access. The LrpC structure reveals a stable octamer supportive of a topological role in dynamic DNA packaging. The structures yield significant clues to the functionality of Lrp/AsnC-type regulators with respect to ligand binding and oligomerization states as well as to their role in specific and global DNA regulation.
 
==About this Structure==
2CFX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFX OCA].
 
==Reference==
Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family., Thaw P, Sedelnikova SE, Muranova T, Wiese S, Ayora S, Alonso JC, Brinkman AB, Akerboom J, van der Oost J, Rafferty JB, Nucleic Acids Res. 2006 Mar 9;34(5):1439-49. Print 2006. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16528101 16528101]
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Rafferty, J B.]]
[[Category: Rafferty JB]]
[[Category: Thaw, P.]]
[[Category: Thaw P]]
[[Category: dna binding]]
[[Category: ffrp]]
[[Category: lrpc]]
[[Category: transcription]]
[[Category: transcriptional regulation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:20:54 2008''

Latest revision as of 09:38, 1 May 2024

Structure of B.subtilis LrpCStructure of B.subtilis LrpC

Structural highlights

2cfx is a 8 chain structure with sequence from Bacillus subtilis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LRPC_BACSU Transcriptional regulator with a possible role in regulation of amino acid metabolism. Plays a role in the growth phase transition.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2cfx, resolution 2.40Å

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