Thrombospondin: Difference between revisions
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<StructureSection load='' size=' | <StructureSection load='' size='350' side='right' caption='Human TSP-1 Nterminal complex with Arixtra heparin (PDB code [[1za4]])' scene='74/748873/Cv/3'> | ||
== Function == | == Function == | ||
Thrombospondin (TSP) are glycoproteins released in response to thrombin stimulation. TSP is a transient component of extracellular matrix in developing tissues<ref>PMID:9304800</ref>. | '''Thrombospondin''' (TSP) are glycoproteins released in response to thrombin stimulation. TSP is a transient component of extracellular matrix in developing tissues<ref>PMID:9304800</ref>. | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
The N-terminal of TSP-1 mediates its interaction with integrins during cell adhesion, with lipoproteinreceptor-related protein during uptake and clearance and with fibrinogen during platelet aggregation. | The N-terminal of TSP-1 mediates its interaction with integrins during cell adhesion, with lipoproteinreceptor-related protein during uptake and clearance and with fibrinogen during platelet aggregation. The <scene name='74/748873/Cv/4'>arginine and lysine side chains of the N-terminal interact with the heparin sulfate groups</scene><ref>PMID:16407063</ref>. | ||
</StructureSection> | </StructureSection> | ||
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*Thrombospondin-1 | *Thrombospondin-1 | ||
**[[1ux6]] – hTSP-1 C-terminal (mutant) + Ca - human<br /> | **[[1ux6]] – hTSP-1 C-terminal (mutant) 831-1170 + Ca - human<br /> | ||
**[[1lsl]], [[3r6b]] – hTSP-1 repeats 2-3<br /> | **[[1lsl]], [[3r6b]] – hTSP-1 repeats 2-3 434-547<br /> | ||
**[[ | **[[1z78]], [[2erf]], [[2es3]], [[2ouh]], [[2ouj]] – hTSP-1 N-terminal 25-233<br /> | ||
**[[7yyk]] – hTSP-1 378-547<br /> | |||
**[[1za4]] – hTSP-1 N-terminal + heparin<br /> | **[[1za4]] – hTSP-1 N-terminal + heparin<br /> | ||
| Line 31: | Line 32: | ||
**[[1yo8]] – hTSP-2 C-terminal<br /> | **[[1yo8]] – hTSP-2 C-terminal<br /> | ||
**[[2rhp]] – hTSP-2 signature domain (mutant)<br /> | **[[2rhp]] – hTSP-2 signature domain (mutant)<br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 11:31, 19 August 2024
FunctionThrombospondin (TSP) are glycoproteins released in response to thrombin stimulation. TSP is a transient component of extracellular matrix in developing tissues[1]. RelevanceTSP-1 and TSP-2 are potent inhibitors of angiogenesis and thus are studied in cancer treatments[2]. DiseaseTSP-2 mutation is associated with coronary artery disease[3]. Structural highlightsThe N-terminal of TSP-1 mediates its interaction with integrins during cell adhesion, with lipoproteinreceptor-related protein during uptake and clearance and with fibrinogen during platelet aggregation. The [4].
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3D structures of thrombospondin3D structures of thrombospondin
Updated on 19-August-2024
ReferencesReferences
- ↑ Adams JC. Thrombospondin-1. Int J Biochem Cell Biol. 1997 Jun;29(6):861-5. PMID:9304800
- ↑ Lawler PR, Lawler J. Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2. Cold Spring Harb Perspect Med. 2012 May;2(5):a006627. doi:, 10.1101/cshperspect.a006627. PMID:22553494 doi:http://dx.doi.org/10.1101/cshperspect.a006627
- ↑ Carlson CB, Liu Y, Keck JL, Mosher DF. Influences of the N700S thrombospondin-1 polymorphism on protein structure and stability. J Biol Chem. 2008 Jul 18;283(29):20069-76. Epub 2008 May 22. PMID:18499674 doi:10.1074/jbc.M800223200
- ↑ Tan K, Duquette M, Liu JH, Zhang R, Joachimiak A, Wang JH, Lawler J. The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin. Structure. 2006 Jan;14(1):33-42. PMID:16407063 doi:10.1016/j.str.2005.09.017