6aw7: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6aw7 is ON HOLD  until Paper Publication
+==2.15A resolution structure of SAH bound catechol O-methyltransferase (COMT) from Nannospalax galili==
+<StructureSection load='6aw7' size='340' side='right'caption='[[6aw7]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6aw7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Nannospalax_galili Nannospalax galili]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AW7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AW7 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6aw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aw7 OCA], [https://pdbe.org/6aw7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6aw7 RCSB], [https://www.ebi.ac.uk/pdbsum/6aw7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6aw7 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0A452CSQ0_NANGA A0A452CSQ0_NANGA] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.[ARBA:ARBA00003256]
-Authors: Lovell, S., Mehzabeen, N., Battaile, K.P., Deng, Y., Hanzlik, R.P., Shams, I., Moskovitz, J.
+==See Also==
+*[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]]
-Description: 2.15A resolution structure of SAH bound catechol O-methyltransferase (COMT) from Nannospalax galili
+__TOC__
-[[Category: Unreleased Structures]]
+</StructureSection>
-[[Category: Moskovitz, J]]
+[[Category: Large Structures]]
-[[Category: Shams, I]]
+[[Category: Nannospalax galili]]
-[[Category: Hanzlik, R.P]]
+[[Category: Battaile KP]]
-[[Category: Battaile, K.P]]
+[[Category: Deng Y]]
-[[Category: Lovell, S]]
+[[Category: Hanzlik RP]]
-[[Category: Deng, Y]]
+[[Category: Lovell S]]
-[[Category: Mehzabeen, N]]
+[[Category: Mehzabeen N]]
+[[Category: Moskovitz J]]
+[[Category: Shams I]]