Haloperoxidase: Difference between revisions
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== Function == | == Function == | ||
'''Haloperoxidases''' catalyze the oxidation of halides by hydrogen peroxide while adding a halide to hydrocarbons. They are classified as '''chloroperoxldase''' (CPO), '''bromoperoxidase''' (BPO) and '''iodoperoxidase''' (IPO) according to the halide which they oxidize. CPO is heme-containing, vanadium-containing or metal-free. BPO from marine algae is vanadium-containing<ref>PMID:19363038</ref>. | '''Haloperoxidases''' catalyze the oxidation of halides by hydrogen peroxide while adding a halide to hydrocarbons. They are classified as '''chloroperoxldase''' (CPO), '''bromoperoxidase''' (BPO) and '''iodoperoxidase''' (IPO) according to the halide which they oxidize. | ||
*'''CPO''' is heme-containing, vanadium-containing or metal-free. | |||
*'''BPO''' is from marine algae is vanadium-containing<ref>PMID:19363038</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
The <scene name='48/486480/Cv/ | The <scene name='48/486480/Cv/5'>vanadate ion shows a trigonal bipyramidal coordination</scene>. The iodine atoms are coordinated to tyrosine residues: <scene name='48/486480/Cv/6'>first coordination site</scene> and <scene name='48/486480/Cv/7'>second coordination site</scene> <ref>PMID:10543953</ref>. Water molecules shown as red spheres. | ||
</StructureSection> | </StructureSection> | ||
==3D structures of haloperoxidase== | ==3D structures of haloperoxidase== | ||
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**[[1qi9]] – AnBPO + I + VO4 – ''Ascophyllum nodosum''<br /> | **[[1qi9]] – AnBPO + I + VO4 – ''Ascophyllum nodosum''<br /> | ||
**[[5aa6]] – AnBPO-2 + VO4<br /> | **[[5aa6]] – AnBPO-2 + VO4<br /> | ||
**[[1up8]], [[1qhb]] – | **[[1up8]], [[1qhb]], [[7qyy]] – CpBPO – ''Corallina pilulifera''<br /> | ||
**[[7qvw]] – CpBPO (mutant) <br /> | |||
**[[7qwi]] – CpBPO + VO4<br /> | |||
**[[7qw3]] – CpBPO (mutant) + Br<br /> | |||
*Vanadium-containing iodoperoxidase | *Vanadium-containing iodoperoxidase | ||