Trehalulose synthase: Difference between revisions
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<StructureSection load='2pwe' size=' | <StructureSection load='2pwe' size='350' side='right' caption='Structure of trehalulose synthase complex with sucrose and Ca+2 ion (green) (PDB code [[2pwe]]).' scene='59/597011/Cv/1'> | ||
== Function == | == Function == | ||
'''Trehalulose synthase''' (THS) converts sucrose to trehalulose (TH)<ref>PMID:7878741</ref>. | '''Trehalulose synthase''' or '''sucrose isomerase''' (THS) converts sucrose to trehalulose (TH)<ref>PMID:7878741</ref>. | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
<scene name='59/597011/Cv/ | <scene name='59/597011/Cv/5'>THS binds sucrose</scene> (water molecules are shown as red spheres) in a <scene name='59/597011/Cv/6'>deep pocket</scene> with mostly conserved residues<ref>PMID:17597061</ref>. | ||
</StructureSection> | </StructureSection> | ||
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**[[4go9]], [[4go8]] – PmTHS (mutant) <br /> | **[[4go9]], [[4go8]] – PmTHS (mutant) <br /> | ||
**[[4h2c]], [[4h8h]] – RhTHS (mutant) - ''Rhizobium''<br /> | **[[4h2c]], [[4h8h]] – RhTHS (mutant) - ''Rhizobium''<br /> | ||
**[[3gbd]] – PrTHS – ''Protaminobacter rubrum''<br /> | |||
**[[4how]] – ErTHS – ''Erwinia rhapontici''<br /> | |||
*Trehalulose synthase complex | *Trehalulose synthase complex | ||
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**[[2pwe]] – PmTHS (mutant) + sucrose<br /> | **[[2pwe]] – PmTHS (mutant) + sucrose<br /> | ||
**[[2pwf]] – PmTHS (mutant) + glucose<br /> | **[[2pwf]] – PmTHS (mutant) + glucose<br /> | ||
**[[4hoz]] – ErTHS + glucose<br /> | |||
**[[4hph]] – ErTHS + sucrose<br /> | |||
**[[4gi6]], [[4h7v]] – RhTHS (mutant) + glucose <br /> | **[[4gi6]], [[4h7v]] – RhTHS (mutant) + glucose <br /> | ||
**[[4gi8]] – RhTHS (mutant) + sucrose<br /> | **[[4gi8]] – RhTHS (mutant) + sucrose<br /> | ||
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**[[4gia]], [[4ha1]] – RhTHS (mutant) + isomaltulose<br /> | **[[4gia]], [[4ha1]] – RhTHS (mutant) + isomaltulose<br /> | ||
**[[4gin]] – RhTHS (mutant) + inhibitor<br /> | **[[4gin]] – RhTHS (mutant) + inhibitor<br /> | ||
**[[3gbe]] – PrTHS + inhibitor<br /> | |||
}} | }} | ||