Nos1: Difference between revisions
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== Location == | == Location == | ||
In humans, three '''nitric oxide synthase''' isoforms are expressed which include NOS1 (neuronal NOS or nNOS), NOS2 (inducible NOS or iNOS), and NOS3 (endothelial NOS or eNOS).<ref>Stuehr DJ. (May 1999) "Mammalian nitric oxide synthases". Biochim. Biophys. Acta 1411 (2–3): 217–30. doi:10.1016/S0005-2728(99)00016-X. PMID 10320659.</ref> NOS1 is located on chromosome 12<ref name="know">Knowles RG, Moncada S. (March 1994) "Nitric oxide synthases in mammals". Biochem. J. 298 (2): 249–58. PMC 1137932. PMID 7510950.</ref> and is expressed in all tissues but has displayed high expression in skeletal muscle as well as in brain, testicular, lung, and kidney tissues.<ref name="ward">Ward ME, Toporsian M, Scott JA, et al. (2005) Hypoxia induces a functionally significant and translationally efficient neuronal NO synthase mRNA variant. Journal of Clinical Investigation. 115(11):3128-3139. doi:10.1172/JCI20806.</ref> Moderate expression has also been observed in heart, adrenal gland, and retinal tissues.<ref name="ward"/> The top ten out of 448 tissues with the highest expression of NOS1 are shown here, all of which are either brain tissue, skeletal muscles, or eye muscles.<ref>Genevisible (ND) 'Expression of P29475' [online] available at https://genevisible.com/tissues/HS/UniProt/P29475</ref> [[Image:PhpPcDTc3AM.jpg]] | In humans, three '''nitric oxide synthase''' isoforms are expressed which include NOS1 (neuronal NOS or nNOS), NOS2 (inducible NOS or iNOS), and NOS3 (endothelial NOS or eNOS) (see [[Nitric Oxide Synthase]]).<ref>Stuehr DJ. (May 1999) "Mammalian nitric oxide synthases". Biochim. Biophys. Acta 1411 (2–3): 217–30. doi:10.1016/S0005-2728(99)00016-X. PMID 10320659.</ref> NOS1 is located on chromosome 12<ref name="know">Knowles RG, Moncada S. (March 1994) "Nitric oxide synthases in mammals". Biochem. J. 298 (2): 249–58. PMC 1137932. PMID 7510950.</ref> and is expressed in all tissues but has displayed high expression in skeletal muscle as well as in brain, testicular, lung, and kidney tissues.<ref name="ward">Ward ME, Toporsian M, Scott JA, et al. (2005) Hypoxia induces a functionally significant and translationally efficient neuronal NO synthase mRNA variant. Journal of Clinical Investigation. 115(11):3128-3139. doi:10.1172/JCI20806.</ref> Moderate expression has also been observed in heart, adrenal gland, and retinal tissues.<ref name="ward"/> The top ten out of 448 tissues with the highest expression of NOS1 are shown here, all of which are either brain tissue, skeletal muscles, or eye muscles.<ref>Genevisible (ND) 'Expression of P29475' [online] available at https://genevisible.com/tissues/HS/UniProt/P29475</ref> [[Image:PhpPcDTc3AM.jpg]] | ||
Figure 1. Microarray expression data for human NOS1 across 448 tissues. | Figure 1. Microarray expression data for human NOS1 across 448 tissues. | ||