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==The crystal structure of the intact human GlnRS==
==The crystal structure of the intact human GlnRS==
<StructureSection load='4ye6' size='340' side='right' caption='[[4ye6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='4ye6' size='340' side='right'caption='[[4ye6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ye6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YE6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YE6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ye6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YE6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YE6 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ye8|4ye8]], [[4ye9|4ye9]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--tRNA_ligase Glutamine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.18 6.1.1.18] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ye6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ye6 OCA], [https://pdbe.org/4ye6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ye6 RCSB], [https://www.ebi.ac.uk/pdbsum/4ye6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ye6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ye6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ye6 OCA], [http://pdbe.org/4ye6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ye6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ye6 PDBsum]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/SYQ_HUMAN SYQ_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/SYQ_HUMAN SYQ_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SYQ_HUMAN SYQ_HUMAN]] Plays a critical role in brain development.<ref>PMID:24656866</ref>
[https://www.uniprot.org/uniprot/SYQ_HUMAN SYQ_HUMAN] Plays a critical role in brain development.<ref>PMID:24656866</ref>  
 
==See Also==
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Glutamine--tRNA ligase]]
[[Category: Homo sapiens]]
[[Category: Ling, J]]
[[Category: Large Structures]]
[[Category: Ognjenovic, J]]
[[Category: Ling J]]
[[Category: Simonovic, M]]
[[Category: Ognjenovic J]]
[[Category: Wu, J]]
[[Category: Simonovic M]]
[[Category: Aminoacyl-trna synthetase]]
[[Category: Wu J]]
[[Category: Class i aar]]
[[Category: L-glutamine]]
[[Category: Ligase]]

Latest revision as of 16:03, 1 March 2024

The crystal structure of the intact human GlnRSThe crystal structure of the intact human GlnRS

Structural highlights

4ye6 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

SYQ_HUMAN The disease is caused by mutations affecting the gene represented in this entry.

Function

SYQ_HUMAN Plays a critical role in brain development.[1]

See Also

References

  1. ↑ Zhang X, Ling J, Barcia G, Jing L, Wu J, Barry BJ, Mochida GH, Hill RS, Weimer JM, Stein Q, Poduri A, Partlow JN, Ville D, Dulac O, Yu TW, Lam AT, Servattalab S, Rodriguez J, Boddaert N, Munnich A, Colleaux L, Zon LI, Soll D, Walsh CA, Nabbout R. Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures. Am J Hum Genet. 2014 Apr 3;94(4):547-58. doi: 10.1016/j.ajhg.2014.03.003. Epub, 2014 Mar 20. PMID:24656866 doi:http://dx.doi.org/10.1016/j.ajhg.2014.03.003

4ye6, resolution 2.40Å

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