Fatty acid-binding protein: Difference between revisions

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<StructureSection load='1fe3' size='350' side='right' scene='48/487562/Cv/1' caption='Human brain-type fatty acid-binding protein complex with oleate (PDB code [[1fe3]]) '>
<StructureSection load='1fe3' size='350' side='right' scene='48/487562/Cv/4' caption='Human brain-type fatty acid-binding protein complex with oleate (PDB code [[1fe3]]) '>


'''Fatty acid-binding protein''' (FABP) are carrier proteins for fatty acids and other lipophilic substances.  They facilitate the transfer of fatty acids between extra- and intracellular membranes.  FABS coordinate lipid trafficking and signaling in cells<ref>PMID:16424607</ref>.  Various FABS differ in their tissue expression. '''IFABP''' is intestinal; '''HFABP''' is heart-type; '''BFABP''' is brain-type; '''LFABP''' is liver-type; '''AFABP''' is adipocyte;  '''LMDABP''' is from flight muscle; '''TFABP''' is from testis; '''EXFABP''' is extracellular.
'''Fatty acid-binding protein''' (FABP) are carrier proteins for fatty acids and other lipophilic substances.  They facilitate the transfer of fatty acids between extra- and intracellular membranes.  FABS coordinate lipid trafficking and signaling in cells<ref>PMID:16424607</ref>.  Various FABS differ in their tissue expression.  
*'''IFABP''' is intestinal;
*'''HFABP''' is heart-type;
*'''BFABP''' is brain-type;  
*'''LFABP''' is liver-type;  
*'''AFABP''' is adipocyte;   
*'''LMDABP''' is from flight muscle;  
*'''TFABP''' is from testis.


== Relevance ==
== Relevance ==
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== Structural insights ==
== Structural insights ==


The <scene name='48/487562/Cv/2'>FABP active site binds fatty acids</scene><ref>PMID:10854433</ref>.   
The <scene name='48/487562/Cv/5'>FABP active site binds fatty acids</scene> ({{Template:ColorKey_Hydrophobic}},  {{Template:ColorKey_Polar}})<ref>PMID:10854433</ref>.   
</StructureSection>


==3D structures of fatty acid-binding protein==
==3D structures of fatty acid-binding protein==
[[Fatty acid-binding protein 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Intestinal fatty acid-binding protein
 
**[[1ael]], [[1a57]], [[1sa8]] - rIFABP – rat – NMR<BR />
**[[1t8v]] - rIFABP (mutant) – NMR<BR />
**[[1ifb]], [[1ifc]] - rIFABP <br />
**[[1dc9]] - rIFABP (mutant)<br />
**[[1kzw]], [[3ifb]] - hIFABP – human – NMR<BR />
**[[1kzx]] - hIFABP (mutant) – NMR<BR />
 
*''Intestinal fatty acid-binding protein binary complex''
 
**[[3akm]] - hIFABP + fatty acid analog<br />
**[[3akn]], [[1icm]], [[1icn]], [[2ifb]] - rIFABP + fatty acid analog<br />
**[[1ure]] - rIFABP + palmitate – NMR<BR />
 
*Epidermal fatty acid-binding protein
 
**[[1b56]], [[1jjj]] - hEFABP <br />
**[[4azr]] - hEFABP + fatty acid<br />
**[[4azn]], [[4azo]] - mEFABP <br />
**[[4azp]], [[4azq]] - mEFABP + fatty acid<br />
**[[4azm]] - hEFABP + inhibitor<br />
 
*Heart-type fatty acid-binding protein
 
**[[1g5w]] - hHFABP – NMR<BR />
**[[3rsw]] – hHFABP<br />
**[[3wbg]] – hHFABP + sulfonate derivative<br />
**[[1bwy]] – HFABP – bovine<br />
 
*Brain-type fatty acid-binding protein
 
**[[1fdq]], [[1jjx]] - hBFABP<br />
**[[1fe3]] - hBFABP + oleate<br />
 
*Liver-type fatty acid-binding protein
 
**[[1p6p]] - LFABP – toad<br />
**[[1tvq]], [[1mvg]] - cLFABP – chicken<br />
**[[1zry]] - cLFABP - NMR<BR />
**[[2f73]], [[3stn]], [[3b2h]], [[3b2i]], [[3b2j]], [[3b2k]], [[3b2l]], [[3vg2]], [[3vg3]], [[3vg4]], [[3vg5]], [[3vg6]], [[3vg7]] - hLFABP<br />
**[[2py1]], [[2l67]], [[2l68]] - hLFABP – NMR<BR />
**[[2ju3]], [[2ju7]] - rLFABP – NMR<BR />
**[[2ft9]] – AmLFABP - ''Ambystoma mexicanum''
 
*''Liver-type fatty acid-binding protein binary complex''
 
**[[3stk]], [[3stm]] - hLFABP + palmitate<br />
**[[2lkk]] - hLFABP + oleate – NMR<br />
**[[2ju8]] - rLFABP + oleate – NMR<BR />
**[[1lfo]] - rLFABP + oleate<br />
**[[1tw4]], [[2jn3]], [[2lfo]] - cLFABP + cholate<br />
**[[2jn3]] - cLFABP + chenodeoxycholate<br />
**[[2k62]] - cLFABP + bile acid-based Gd chelate<br />
**[[2ftb]] - AmLFABP + oleate<br />
**[[2qo4]] – zLFABP + cholate – zebrafish<br />
**[[2qo5]], [[2qo6]] – zLFABP (mutant) + cholate <br />
 
*Adipocyte fatty acid-binding protein
 
**[[1tou]], [[2hnx]], [[3q6l]], [[3rzy]] - hAFABP<br />
**[[1lib]], [[1alb]] – mAFABP<br />
**[[1g7n]], [[1ab0]], [[1acd]] - mAFABP (mutant) <br />
**[[1tow]] - hAFABP + carbazole butanoic acid<br />
**[[2nnq]], [[3fr2]], [[3fr4]], [[3fr5]] - hAFABP + inhibitor<br />
**[[3p6c]] - hAFABP + citrate<br />
**[[3p6d]], [[3p6e]] - hAFABP + propionate derivative<br />
**[[3p6f]] - hAFABP + phenyl-butyrate<br />
**[[3p6g]], [[3p6h]] - hAFABP + ibuprofen<br />
**[[2qm9]] - mAFABP + troglitazone <br />
**[[2q9s]], [[1lid]], [[1lie]], [[1lif]], [[1adl]] - mAFABP + fatty acid<br />
**[[1g74]] - mAFABP (mutant) + fatty acid <br />
**[[3hk1]], [[3js1]], [[3jsq]] - mAFABP + inhibitor<br />
**[[1lic]], [[2ans]] – mAFABP + sulfonic acid derivative<br />
**[[1a18]] - mAFABP + phenanthroline <br />
**[[1a2d]] - mAFABP + pyridoxamine <br />
 
*Flight muscle fatty acid-binding protein
 
**[[2flj]], [[1ftp]] - LMFABP – locust
 
*Muscle fatty acid-binding protein
 
**[[2hmb]] – hMFABP <br />
**[[1hmr]], [[1hms]], [[1hmt]] – hMFABP + fatty acid<br />
 
*Testis fatty acid-binding protein
 
**[[4a60]] - hTFABP
 
*Ileal bile acid-binding protein
 
**[[3elx]] – zIBABP <br />
**[[3elz]], [[3em0]] – zIBABP + cholate<br />
 
*Extracellular fatty acid-binding protein
 
**[[2kt4]] - qEXFABP – quail<br />
**[[2lbv]] - qEXFABS + enterobactin<br />
**[[3sao]] - cEXFABP + myristoyl lysophosphatidic acid
 
*Other fatty acid-binding protein


**[[2poa]] - SmFABP (mutant) - ''Schistosoma mansoni'' – NMR<BR />
**[[1mdc]] – FABP – tobacco hornworm<br />
**[[4jgx]] - FABP – ''Yarrowia lipolytica''<br />
**[[1vyf]], [[1vyg]] – SmFABP + fatty acid<br />
**[[3w9k]] – FABP + fatty acid – ''Sulfolobus tokodaii''<br />
}}
== References ==
== References ==
<references/>
<references/>


[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 08:31, 23 June 2024


Fatty acid-binding protein (FABP) are carrier proteins for fatty acids and other lipophilic substances. They facilitate the transfer of fatty acids between extra- and intracellular membranes. FABS coordinate lipid trafficking and signaling in cells[1]. Various FABS differ in their tissue expression.

  • IFABP is intestinal;
  • HFABP is heart-type;
  • BFABP is brain-type;
  • LFABP is liver-type;
  • AFABP is adipocyte;
  • LMDABP is from flight muscle;
  • TFABP is from testis.

Relevance

Some FABSs are linked to metabolic and inflammatory pathways.

Structural insights

The (Hydrophobic, Polar)[2].

3D structures of fatty acid-binding protein

Fatty acid-binding protein 3D structures


Human brain-type fatty acid-binding protein complex with oleate (PDB code 1fe3)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Chmurzynska A. The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism. J Appl Genet. 2006;47(1):39-48. PMID:16424607 doi:http://dx.doi.org/10.1007/BF03194597
  2. ↑ Balendiran GK, Schnutgen F, Scapin G, Borchers T, Xhong N, Lim K, Godbout R, Spener F, Sacchettini JC. Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein. J Biol Chem. 2000 Sep 1;275(35):27045-54. PMID:10854433 doi:10.1074/jbc.M003001200

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