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| | <StructureSection load='1a82' size='450' side='right' caption='Dethiobiotin synthetase complex with dethiobiotin, ATP and Mg+2 ion (green) (PDB entry [[1a82]])' scene='49/493028/Cv/1'> |
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| <StructureSection load='1a82' size='350' side='right' caption='Dethiobiotin synthetase complex with dethiobiotin, ADP (stick model) and Mg+2 ion (green) (PDB entry [[1a82]])' scene=''>
| | '''Dethiobiotin synthetase''' (DTBS) or '''ATP-depenent dethiobiotin synthetase''' catalyzes the first ring closure in the biotin synthesis. The reaction transforms 7,8-diaminononanoate (DAN), ATP and CO2 to dethiobiotin (DTB), ADP and phosphate.<ref>PMID:4921568</ref> |
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| '''Dethiobiotin synthetase''' (DTBS) catalyzes the first ring closure in the biotin synthesis. The reaction transforms 7,8-diaminononanoate (DAN), ATP and CO2 to dethiobiotin (DTB), ADP and phosphate.<ref>PMID:4921568</ref> | |
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| == Structural highlights == | | == Structural highlights == |
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| The active site contains the substrate, Mg<sup>+2</sup> ion and ADP. | | The <scene name='49/493028/Cv/5'>active site contains the substrate (DAN), Mg+2 ion and ATP</scene>.<ref>PMID:9576910</ref> |
| </StructureSection> | | |
| ==3D dethiobiotin synthetase== | | ==3D dethiobiotin synthetase== |
| | [[Dethiobiotin synthetase 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *DTBS
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| **[[1dbs]], [[1dts]], [[1byi]] – EcDTBS – ''Escherichia coli''<br />
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| **[[2qmo]] – HpDTBS – ''Helicobacter pylori''<br />
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| **[[3fgn]] – MtDTBS – ''Mycobacterium tuberculosis''<br />
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| **[[3of5]] – DTBS – ''Francicella tularensis''
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| *DTBS binary complex
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| **[[3fmf]] – MtDTBS + DAN<br />
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| **[[1dad]] – EcDTBS + ADP<BR />
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| **[[1dae]] - EcDTBS + nonanedioate derivative<br />
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| **[[3fmi]] – MtDTBS + aminopelargonic acid<br />
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| **[[1dai]] - EcDTBS + DAN
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| *DTBS ternary complex
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| **[[3qxc]] - HpDTBS + Mg + ATP<BR />
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| **[[1daf]] - EcDTBS + DAN + ADP<BR />
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| **[[1dag]] - EcDTBS + DAN + ATP derivative<br />
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| **[[3qxj]] - HpDTBS + Mg + ATP<BR />
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| **[[3qxs]] - HpDTBS + Mg + phosphoaminophosphonic acid
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| *DTBS quaternary complex
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| **[[1dah]] - EcDTBS + DAN + Mn + ATP derivative<br />
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| **[[1bs1]] - EcDTBS + DTB + Mg + ADP<BR />
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| **[[1a82]] - EcDTBS + DAN + Mg + ATP<BR />
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| **[[3fpa]] - MtDTBS + DTB + Mg + phosphate <br />
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| **[[3mle]] - HpDTBS + Mg + phosphate + ADP<BR />
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| **[[3qy0]] - HpDTBS + Mg + phosphate + GDP<BR />
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| *DTBS higher complexes
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| **[[1dam]] - EcDTBS + DTB + Mg + phosphate + ADP<BR />
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| **[[1dak]] - EcDTBS + DAN + mixed anhydride + Mg + phosphate + ADP<BR />
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| **[[3qxh]] - HpDTBS + aminooctanoic acid + Mg + phosphate + ADP<BR />
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| **[[3qxx]] - HpDTBS + aminooctanoic acid + Mg + phosphate + GTP<BR />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |