Complexin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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+<StructureSection load='3rk3' size='350' side='right' caption='Human complexin (magenta) as part of the SNARE complex (VAMP2 - cyan; syntaxin - green; SNAP25 (pink and yellow) (PDB entry [[3rk3]])' scene='46/466533/Cv/1'>
-<StructureSection load='3rk3' size='350' side='right' caption='Human complexin (magenta) as part of the SNARE complex (VAMP2 - grey; syntaxin - green; SNAP25 (pink and yellow) (PDB entry [[3rk3]])' scene=''>
+== Function ==
+'''Complexin''' (CPLX) is the protein which binds the SNARE protein complex with high affinity.  CPLX acts as both inhibitor and facilitator of vesicle fusion and neurotransmitter release at the synapse.  CPLX clamps SNARE complexes to prevent vesicle fusion while in another conformation it releases the SNARE complex allowing fusion.<ref>PMID:12200427</ref>
+== Structural highlights ==
+<scene name='46/466533/Cv/2'>CPLX binds to v-SNARE protein VAMP2 and to t-SNARE proteins SNAP25 and syntaxin</scene> (PDB entry [[3rk3]]).<ref>PMID:21785414</ref>
-'''Complexin''' (CPLX) is the protein which binds the SNARE protein complex with high affinity.  CPLX acts as both inhibitor and facilitator of vescicle fusion and neurotransmitter release at the synapse.  CPLX clamps SNARE complexes to prevent vescicle fusion while in another conformation it releases the SNARE complex allowing fusion.<ref>PMID:12200427</ref>
 </StructureSection>
 ==3D structures of complexin==
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 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[1kil]] – CPLX + SNARE – rat
+[[3rk3]], [[3rl0]] - CPLX + Vamp2 + Syntaxin 1A + Snap25 – human<br />
+[[1kil]] – rCPLX + Vamp2 + Syntaxin 1A + Snap25 – rat<br />
-[[3rk3]], [[3rl0]] - CPLX + SNARE – human
+[[5w5c]], [[5w5d]] - rCPLX + Vamp2 + Syntaxin 1A + Snap25 + synaptotagmin <br />
 == References ==
 <references/>
 [[Category:Topic Page]]