Adenosine kinase: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
Michal Harel (talk | contribs)
31,761 edits
No edit summary
Michal Harel (talk | contribs)
31,761 edits
No edit summary
 
(5 intermediate revisions by 2 users not shown)
Line 11: Line 11:
== Structural highlights ==
== Structural highlights ==


AdK consists of a <scene name='57/573962/Cv/2'>large α/β domain with 9 β strands and 8 α helices and a small capping α/β domain with 5 β strands and 2 α helices</scene>. The <scene name='57/573962/Cv/3'>active site</scene> is formed along the edge of the β sheet in the large domain.
AdK consists of a <scene name='57/573962/Cv/4'>large α/β domain with 9 β strands and 8 α helices and a small capping α/β domain with 5 β strands and 2 α helices</scene> (PDB entry [[1bx4]]).<ref>PMID:9843365</ref>
</StructureSection>
*<scene name='57/573962/Cv/6'>1st adenosine binding site</scene>. Water molecules are shown as red spheres.
*<scene name='57/573962/Cv/7'>Cl coordination site</scene>.
*<scene name='57/573962/Cv/8'>Cl/Mg cluster coordination site</scene>.
*<scene name='57/573962/Cv/11'>2nd adenosine binding site</scene>.


==3D structures of adenosine kinase==
==3D structures of adenosine kinase==
[[Adenosine kinase 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Adenosine kinase
 
**[[1lio]] – TgAdK – ''Toxoplasma gondii''<br />
**[[2pkf]] – MtAdK – ''Mycobacterium tuberculosis''<br />
**[[4n08]] – TbAdK – ''Trypanosoma brucei''<br />
 
*Adenosine kinase binary complex
 
**[[1bx4]] – hAdK + adenosine - human<br />
**[[2i6a]], [[2i6b]] – hAdK + prodrug <br />
**[[4o1l]] – hAdK + inhibitor <br />
**[[1dgm]], [[1lik]] – TgAdK + adenosine <br />
**[[2a9y]] – TgAdK (mutant) + dimethyladenosine <br />
**[[2abs]] – TgAdK (mutant) + AMP-PCP<br />
**[[2aa0]] – TgAdK (mutant) + methylthiopurine <br />
**[[2pkk]], [[4ube]] – MtAdK + fluoroadenosine <br />
**[[2pkn]] – MtAdK + AMP-PCP<br />
**[[2pkm]] – MtAdK + adenosine <br />
**[[4o1g]] – MtAdK + γ-thio-ATP <br />
**[[4pvv]] – MtAdK + inhibitor <br />
**[[3loo]] – AdK + adenosine tetraphosphate – ''Anopheles gambiae''<br />
**[[2xtb]] – TbAdK + morpholine <br />
 
*Adenosine kinase ternary complex


**[[1lii]] – TgAdK + adenosine + AMP-PCP<br />
**[[2a9z]] – TgAdK (mutant) + dimethyladenosine + AMP-PCP<br />
**[[1lij]] – TgAdK + prodrug + AMP-PCP<br />
**[[2ab8]] – TgAdK (mutant) + methylthiopurine + AMP-PCP<br />
**[[3ubo]] – AdK + adenosine + ADP – ''Sinorhizobium meliloti''<br />
**[[4dc3]] – AdK + adenosine + fluoroadenosine – ''Schistosoma masoni''<br />
**[[4n09]] – TbAdK + adenosine + ADP <br />
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 14:07, 28 February 2019


Function

Adenosine kinase (AdK) catalyzes the transfer of phosphate from ATP to adenosine to produce AMP. AMP-PCP is a non-hydrolyzable ATP analog.[1]

Disease

AdK deficiency causes hypermethioninemia. Overexpression of AdK in the brain leads to decrease of adenosine and is believed as the main cause of epilepsy.

Structural highlights

AdK consists of a (PDB entry 1bx4).[2]

  • . Water molecules are shown as red spheres.
  • .
  • .
  • .

3D structures of adenosine kinase

Adenosine kinase 3D structures


Structure of human adenosine kinase complex with adenosine, Mg+2 (small light green) and Cl- (large, deep green) ions (PDB entry 1bx4)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Park J, Gupta RS. Adenosine kinase and ribokinase--the RK family of proteins. Cell Mol Life Sci. 2008 Sep;65(18):2875-96. doi: 10.1007/s00018-008-8123-1. PMID:18560757 doi:http://dx.doi.org/10.1007/s00018-008-8123-1
  2. ↑ Mathews II, Erion MD, Ealick SE. Structure of human adenosine kinase at 1.5 A resolution. Biochemistry. 1998 Nov 10;37(45):15607-20. PMID:9843365 doi:10.1021/bi9815445

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=Adenosine_kinase&oldid=3006760"