Adapter molecule crk: Difference between revisions

Latest revision as of 18:38, 20 January 2020

Function

Adapter molecule crk (Crk) (CT10 Regulatior of Kinase) or p38 is a proto-oncogene which participates in the Reelin signaling cascade. Crk binds to several tyrosine-phosphorylated proteins.^[1] See also SRC and Oncogenes & Tumor Suppressor Genes.

Structural highlights

Crk domains include several N-terminal SH2 and C-terminal SH3 domains. (1cka)^[2] is shown.

3D structures of adapter molecule crk

Adapter molecule crk 3D structures

Structure of mouse Crk N terminal SH3 domain (magenta) complex with proline-rich peptide (green) (PDB entry 1cka)

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Collins BM, McCoy AJ, Kent HM, Evans PR, Owen DJ. Molecular architecture and functional model of the endocytic AP2 complex. Cell. 2002 May 17;109(4):523-35. PMID:12086608
↑ Wu X, Knudsen B, Feller SM, Zheng J, Sali A, Cowburn D, Hanafusa H, Kuriyan J. Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk. Structure. 1995 Feb 15;3(2):215-26. PMID:7735837

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Collins BM, McCoy AJ, Kent HM, Evans PR, Owen DJ. Molecular architecture and functional model of the endocytic AP2 complex. Cell. 2002 May 17;109(4):523-35. PMID:12086608

[2] Wu X, Knudsen B, Feller SM, Zheng J, Sali A, Cowburn D, Hanafusa H, Kuriyan J. Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk. Structure. 1995 Feb 15;3(2):215-26. PMID:7735837

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[2]

@@ Line 1: / Line 1: @@
-<StructureSection load='1cka' size='350' side='right' caption='Structure of mouse Crk N terminal SH3 domain (grey) complex with proline-rich peptide (green) (PDB entry [[1cka]])' scene=''>
+<StructureSection load='1cka' size='350' side='right' caption='Structure of mouse Crk N terminal SH3 domain (magenta) complex with proline-rich peptide (green) (PDB entry [[1cka]])' scene='57/573988/Cv/1'>
 == Function ==
-'''Adapter molecule crk''' (Crk) ('''C'''T10 '''R'''egulatior of '''K'''inase) or '''p38''' is a proto-oncogene which participates in the Reelin signaling cascade.  Crk binds to several tyrosine-phosphorylated proteins.
+'''Adapter molecule crk''' (Crk) ('''C'''T10 '''R'''egulatior of '''K'''inase) or '''p38''' is a proto-oncogene which participates in the Reelin signaling cascade.  Crk binds to several tyrosine-phosphorylated proteins.<ref>PMID:12086608</ref> See also [[SRC]] and [[Oncogenes & Tumor Suppressor Genes]].
 == Structural highlights ==
-Crk domains include several SH2 and SH3 domains.
+Crk domains include several N-terminal SH2 and C-terminal SH3 domains. <scene name='57/573988/Cv/4'>Mouse Crk N terminal SH3 domain complex with proline-rich peptide</scene> ([[1cka]])<ref>PMID:7735837</ref> is shown.
-==3D structures of adpter molecule crk==
+==3D structures of adapter molecule crk==
+[[Adapter molecule crk 3D structures]]
-[[1m30]], [[1m3a]], [[1m3b]], [[1m3c]] – mCrk N terminal SH3 (mutant) – mouse - NMR<br />
+</StructureSection>
-[[2ggr]] – mCrk C terminal SH3 - NMR<br />
-[[2l3p]], [[2l3q]], [[2l3s]] – Crk residues 220-297 – chicken – NMR<br />
-[[1cka]], [[1ckb]] – mCrk N terminal SH3 + proline-rich peptide<br />
-[[1b07]] – mCrk N terminal SH3 + SH3 peptoid inhibitor<br />
-[[1ju5]] – hCrk SH2 + phosphopeptide + Abl SH3 - human<br />
+== References ==
+<references/>
 [[Category:Topic Page]]