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Cyclin-dependent kinase regulatory subunit: Difference between revisions

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<StructureSection load='1dks' size='340' side='right' caption='Human CKS 1 complex with phosphate (PDB code [[1dks]])' scene=''>
<StructureSection load='1dks' size='340' side='right' caption='Human CKS-1 complex with phosphate (PDB code [[1dks]])' scene=''>
{{STRUCTURE_1x9d|  PDB=1x9d  | SIZE=300| SCENE= |left|  CAPTION=Human α-mannosidase class I complex with mannopyranoside, sulfate, 1,4-butanediol, Ca+2 ion, [[1x9d]] }}
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
'''Cyclin-dependent kinase regulatory subunit''' (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex.  CKS binds to the catalytic subunit of CDK see complex structure in the figure at top left.  CKS1 is essential for CDK5 functioning in neuronal diferentiation.  CKS exists as hexamer of homodimers and can bind six kinase molecules.
== Function ==
== Function ==


== Disease ==
'''Cyclin-dependent kinase regulatory subunit''' (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex.  CKS binds to the catalytic subunit of CDK see complex structure in <scene name='71/715441/Pdb4yc6/1'>pdb 4yc6</scene> where CDK1 is in grey, pink, magenta and gold and CKS1 i in green, yellow, cyan and red. 
*'''CKS1''' is essential for CDK5 functioning in neuronal differentiation.<ref>PMID:8491379</ref> 
*'''CKS2''' is implicated as an oncogene in various malignancies.<ref>PMID:31781310</ref>


== Relevance ==
== Structural highlights ==


== Structural highlights ==
CKS exists as hexamer of homodimers and can bind six kinase molecules.


</StructureSection>
== 3D Structures of cyclin-dependent kinase regulatory subunit ==
== 3D Structures of cyclin-dependent kinase regulatory subunit ==
[[Cyclin-dependent kinase regulatory subunit 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*CKS
 
**[[4lpa]], [[1qb3]] – yCKS 1 - yeast<br />
**[[3qy2]] – yCKS 1 (mutant)<br />
**[[1puc]], [[1sce]] – fyCKS 1 – fission yeast<br />
**[[1dks]], [[1dkt]] – hCKS 1 - human<br />
**[[1cks]] – hCKS 2<br />
 
*CKS complexes


**[[4yc6]] – hCKS 1 + CDK1 <br />
**[[1buh]] – hCKS 1 + CDK2<br />
**[[1h4l]], [[1ung]] – hCKS 1 + CDK5<br />
**[[1unh]], [[1unl]] – hCKS 1 + CDK5 + inhibitor<br />
**[[3o0g]] – hCKS 1 + CDK5 + ATP analog<br />
**[[2ass]] – hCKS 1 + Skp1 + Skp2<br />
**[[2ast]] – hCKS 1 + Skp1 + Skp2 + CDK inhibitor peptide<br />
**[[4y72]] – hCKS 2 + cyclin B1 + CDK1<br />
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]

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Michal Harel, Alexander Berchansky
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