2jp6: Difference between revisions

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==Structural and functional characterization of the recombinant form of the Kv1.3 channel blocker Tc32==
==Structural and functional characterization of the recombinant form of the Kv1.3 channel blocker Tc32==
<StructureSection load='2jp6' size='340' side='right' caption='[[2jp6]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
<StructureSection load='2jp6' size='340' side='right'caption='[[2jp6]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2jp6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Amazonian_scorpion Amazonian scorpion]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JP6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JP6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2jp6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tityus_obscurus Tityus obscurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JP6 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jp6 OCA], [http://pdbe.org/2jp6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jp6 RCSB], [http://www.ebi.ac.uk/pdbsum/2jp6 PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 25 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jp6 OCA], [https://pdbe.org/2jp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jp6 RCSB], [https://www.ebi.ac.uk/pdbsum/2jp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jp6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KA181_TITOB KA181_TITOB]] Reversible blocker of both Kv1.3/KCNA3 potassium channels (high affinity) and Shaker B (mammalian Kv1.1 analog) potassium channels (very low affinity).<ref>PMID:12445473</ref>
[https://www.uniprot.org/uniprot/KA181_TITOB KA181_TITOB] Reversible blocker of both Kv1.3/KCNA3 potassium channels (high affinity) and Shaker B (mammalian Kv1.1 analog) potassium channels (very low affinity).<ref>PMID:12445473</ref>  


==See Also==
==See Also==
*[[Potassium channel toxin|Potassium channel toxin]]
*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Amazonian scorpion]]
[[Category: Large Structures]]
[[Category: Belluzzi, O]]
[[Category: Tityus obscurus]]
[[Category: Pertinhez, T A]]
[[Category: Belluzzi O]]
[[Category: Pignatelli, A]]
[[Category: Pertinhez TA]]
[[Category: Sforca, M L]]
[[Category: Pignatelli A]]
[[Category: Spisni, A]]
[[Category: Sforca ML]]
[[Category: Stehling, E G]]
[[Category: Spisni A]]
[[Category: Zanchin, N I]]
[[Category: Stehling EG]]
[[Category: Toxin]]
[[Category: Zanchin NI]]

Latest revision as of 12:13, 6 November 2024

Structural and functional characterization of the recombinant form of the Kv1.3 channel blocker Tc32Structural and functional characterization of the recombinant form of the Kv1.3 channel blocker Tc32

Structural highlights

2jp6 is a 1 chain structure with sequence from Tityus obscurus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR, 25 models
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KA181_TITOB Reversible blocker of both Kv1.3/KCNA3 potassium channels (high affinity) and Shaker B (mammalian Kv1.1 analog) potassium channels (very low affinity).[1]

See Also

References

  1. ↑ Batista CV, Gomez-Lagunas F, Rodriguez de la Vega RC, Hajdu P, Panyi G, Gaspar R, Possani LD. Two novel toxins from the Amazonian scorpion Tityus cambridgei that block Kv1.3 and Shaker B K(+)-channels with distinctly different affinities. Biochim Biophys Acta. 2002 Dec 16;1601(2):123-31. PMID:12445473
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