2jp6

Structural and functional characterization of the recombinant form of the Kv1.3 channel blocker Tc32Structural and functional characterization of the recombinant form of the Kv1.3 channel blocker Tc32

Structural highlights

2jp6 is a 1 chain structure with sequence from Tityus obscurus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR, 25 models
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KA181_TITOB Reversible blocker of both Kv1.3/KCNA3 potassium channels (high affinity) and Shaker B (mammalian Kv1.1 analog) potassium channels (very low affinity).^[1]

References

↑ Batista CV, Gomez-Lagunas F, Rodriguez de la Vega RC, Hajdu P, Panyi G, Gaspar R, Possani LD. Two novel toxins from the Amazonian scorpion Tityus cambridgei that block Kv1.3 and Shaker B K(+)-channels with distinctly different affinities. Biochim Biophys Acta. 2002 Dec 16;1601(2):123-31. PMID:12445473

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OCA

[1] Batista CV, Gomez-Lagunas F, Rodriguez de la Vega RC, Hajdu P, Panyi G, Gaspar R, Possani LD. Two novel toxins from the Amazonian scorpion Tityus cambridgei that block Kv1.3 and Shaker B K(+)-channels with distinctly different affinities. Biochim Biophys Acta. 2002 Dec 16;1601(2):123-31. PMID:12445473

[1]

2jp6

Structural and functional characterization of the recombinant form of the Kv1.3 channel blocker Tc32Structural and functional characterization of the recombinant form of the Kv1.3 channel blocker Tc32

Structural highlights

Function

See Also

References

Contents

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