NADP-dependent malic enzyme: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
PDBe (talk | contribs)
Bots
90 edits
No edit summary
Michal Harel (talk | contribs)
31,761 edits
No edit summary
 
(49 intermediate revisions by 3 users not shown)
Line 1: Line 1:
== Lysozyme ==
<StructureSection load='3wja' size='340' side='right' caption='The best structure for NADP-dependent malic enzyme shown: [[3wja]]' scene=''>
<StructureSection load='1swy' size='340' side='right' caption='Caption for this structure' scene=''>
Best example is PDB entry [[3wja]] and is shown in the viewer.<br>
Best example is 1swy<br>
==Catalytic Activity ==
Molecule Lysozyme, also known as Lysozyme, CP-7 lysin, Muramidase, Endolysin, 1,4-beta-N-acetylmuramidase, Lysis protein, CP-1 lysin, Lysozyme murein hydrolase, Protein gp17, Transglycosylase, Hevamine-A, Chitinase and L-alanyl-D-glutamate peptidase.
Oxaloacetate = pyruvate + CO(2).Data source: Uniprot [http://www.uniprot.org/uniprot/P48163 P48163]<br>
== Function ==
Or the decarboxylation of malate to pyruvate<ref>PMID:8187880</ref>.
lysozyme activity<br>
catalytic activity<br>
hydrolase activity<br>
hydrolase activity, acting on glycosyl bonds<br>
carbon-oxygen lyase activity, acting on polysaccharides<br>
lyase activity<br>
chitinase activity<br>
hydrolase activity, hydrolyzing O-glycosyl compounds<br>
sequence-specific DNA binding<br>


== Disease ==
== Relevance ==
== Structural highlights ==
== Biological process ==
== Biological process ==
Is involved in the following biological processes:<br>
Is involved in the following biological processes:<br>
cell wall macromolecule catabolic process<br>
malate metabolic process<br>
peptidoglycan catabolic process<br>
oxidation-reduction process<br>
metabolic process<br>
response to carbohydrate<br>
defense response to bacterium<br>
response to hormone<br>
cytolysis<br>
viral release from host cell<br>
carbohydrate metabolic process<br>
carbohydrate metabolic process<br>
chitin catabolic process<br>
protein tetramerization<br>
polysaccharide catabolic process<br>
regulation of NADP metabolic process<br>
cytolysis by virus of host cell<br>
NADP biosynthetic process<br>
cell wall organization<br>
small molecule metabolic process<br>
cellular lipid metabolic process<br>
== In structures ==
== In structures ==
Lysozyme is found in 595 PDB entries<br>
NADP-dependent malic enzyme is found in 3 PDB entries<br>
Homo sapiens (2 PDB entries): <br>
*<b>Eukaryota</b> (3 PDB entries): <br>
[[4uis]] <div class="pdb-prints 4uis"></div> 4.4 A resolution. [http://www.ebi.ac.uk/pdbe/entry/emdb/emd-2974 emd-2974]. Other macromolecules also in this entry: GAMMA-SECRETASE, Nicastrin, Presenilin-1 NTF subunit, GAMMA-SECRETASE.<br>
**<b>Homo sapiens</b> (2 PDB entries): <br>
Enterobacteria phage P22 (2 PDB entries): <br>
***[[3wja]] <div class="pdb-prints 3wja"></div>
[[2anv]] <div class="pdb-prints 2anv"></div> 1.04 A resolution. <br>
***Title: The crystal structure of human cytosolic NADP(+)-dependent malic enzyme in apo form
Enterobacteria phage P21 (2 PDB entries): <br>
***2.548 A resolution
[[3hdf]] <div class="pdb-prints 3hdf"></div> 1.7 A resolution. <br>
***[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific_name:%22Homo%20sapiens%22&all_molecule_names:%22NADP-dependent%20malic%20enzyme%22&!chimera:y Search the PDB for NADP-dependent malic enzyme from Homo sapiens]
Hevea brasiliensis (2 PDB entries): <br>
**<b>Columba livia</b> (1 PDB entries): <br>
[[1kqy]] <div class="pdb-prints 1kqy"></div> 1.92 A resolution. <br>
***[[1gq2]] <div class="pdb-prints 1gq2"></div>
Escherichia phage T5 (2 PDB entries): <br>
***Title: MALIC ENZYME FROM PIGEON LIVER
[[2mxz]] <div class="pdb-prints 2mxz"></div> N/A A resolution. <br>
***2.5 A resolution
Streptococcus phage CP-7 (2 PDB entries): <br>
== Alternative names for NADP-dependent malic enzyme ==
[[4cvd]] <div class="pdb-prints 4cvd"></div> 1.666 A resolution. <br>
Molecule '''NADP-dependent malic enzyme''', also known as '''NADP-ME''', '''NADP-dependent malic enzyme''' and '''Malic enzyme 1'''.
Antheraea mylitta (2 PDB entries): <br>
 
[[1iiz]] <div class="pdb-prints 1iiz"></div> 2.4 A resolution. <br>
== 3D Structures of NADP-dependent malic enzyme ==
Mus musculus (2 PDB entries): <br>
 
[[1iak]] <div class="pdb-prints 1iak"></div> 1.9 A resolution. Other macromolecules also in this entry: H-2 class II histocompatibility antigen, A-K beta chain, H-2 class II histocompatibility antigen, A-K alpha chain.<br>
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Bombyx mori (2 PDB entries): <br>
[[1gd6]] <div class="pdb-prints 1gd6"></div> 2.5 A resolution. <br>
 
Streptococcus phage Cp-1 (2 PDB entries): <br>
[[3wja]], [[2aw5]] – hME - human<br />
[[2j8g]] <div class="pdb-prints 2j8g"></div> 1.69 A resolution. <br>
[[7x11]], [[7x12]] – hME1 + NADP<br />
Enterobacteria phage T4 (2 PDB entries): <br>
[[8e76]], [[8eyn]] – hME3<br />
[[1swy]] <div class="pdb-prints 1swy"></div> 1.06 A resolution. <br>
[[8e78]], [[8e8o]], [[8eyo]] – hME3 + NADP<br />
Enterobacteria phage P1 (2 PDB entries): <br>
[[1gq2]] – ME + NADP - pigeon<br />
[[1xju]] <div class="pdb-prints 1xju"></div> 1.07 A resolution. <br>
[[5ou5]] – ME - maize<br />
Enterobacteria phage lambda (2 PDB entries): <br>
 
[[1am7]] <div class="pdb-prints 1am7"></div> 2.3 A resolution. <br>
== References ==
Meretrix lusoria (2 PDB entries): <br>
<references/>
[[4pj2]] <div class="pdb-prints 4pj2"></div> 1.24 A resolution. Other macromolecules also in this entry: Putative exported protein, Putative exported protein.<br>
[[Category:Topic Page]][[Category:PDBe]]
Ruditapes philippinarum (2 PDB entries): <br>
[[2dqa]] <div class="pdb-prints 2dqa"></div> 1.6 A resolution. <br>
Escherichia coli (2 PDB entries): <br>
[[2qb0]] <div class="pdb-prints 2qb0"></div> 2.56 A resolution. Other macromolecules also in this entry: Transcription factor ETV6, Transcription factor ETV6.<br>

Latest revision as of 12:11, 11 July 2023

<StructureSection load='3wja' size='340' side='right' caption='The best structure for NADP-dependent malic enzyme shown: 3wja' scene=> Best example is PDB entry 3wja and is shown in the viewer.

Catalytic ActivityCatalytic Activity

Oxaloacetate = pyruvate + CO(2).Data source: Uniprot P48163
Or the decarboxylation of malate to pyruvate[1].

Biological processBiological process

Is involved in the following biological processes:
malate metabolic process
oxidation-reduction process
response to carbohydrate
response to hormone
carbohydrate metabolic process
protein tetramerization
regulation of NADP metabolic process
NADP biosynthetic process
small molecule metabolic process
cellular lipid metabolic process

In structuresIn structures

NADP-dependent malic enzyme is found in 3 PDB entries

Alternative names for NADP-dependent malic enzymeAlternative names for NADP-dependent malic enzyme

Molecule NADP-dependent malic enzyme, also known as NADP-ME, NADP-dependent malic enzyme and Malic enzyme 1.

3D Structures of NADP-dependent malic enzyme3D Structures of NADP-dependent malic enzyme

Updated on 11-July-2023


3wja, 2aw5 – hME - human
7x11, 7x12 – hME1 + NADP
8e76, 8eyn – hME3
8e78, 8e8o, 8eyo – hME3 + NADP
1gq2 – ME + NADP - pigeon
5ou5 – ME - maize

ReferencesReferences

  1. ↑ Loeber G, Dworkin MB, Infante A, Ahorn H. Characterization of cytosolic malic enzyme in human tumor cells. FEBS Lett. 1994 May 16;344(2-3):181-6. PMID:8187880

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

PDBe, Jaime Prilusky, Michal Harel
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=NADP-dependent_malic_enzyme&oldid=3802018"