8e8o

Cryo-EM structure of human ME3 in the presence of citrateCryo-EM structure of human ME3 in the presence of citrate

Structural highlights

8e8o is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 2.77Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MAON_HUMAN Catalyzes the oxidative decarboxylation of (S)-malate to pyruvate using NADP(+) as a cofactor (PubMed:7818469). Can also reverse the decarboxylation reaction, but only with significantly lower efficiency (PubMed:7818469).^[1]

References

↑ Loeber G, Maurer-Fogy I, Schwendenwein R. Purification, cDNA cloning and heterologous expression of the human mitochondrial NADP(+)-dependent malic enzyme. Biochem J. 1994 Dec 15;304 ( Pt 3)(Pt 3):687-92. PMID:7818469 doi:10.1042/bj3040687

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OCA

[1] Loeber G, Maurer-Fogy I, Schwendenwein R. Purification, cDNA cloning and heterologous expression of the human mitochondrial NADP(+)-dependent malic enzyme. Biochem J. 1994 Dec 15;304 ( Pt 3)(Pt 3):687-92. PMID:7818469 doi:10.1042/bj3040687

[1]

8e8o

Cryo-EM structure of human ME3 in the presence of citrateCryo-EM structure of human ME3 in the presence of citrate

Structural highlights

Function

See Also

References

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8e8o

Cryo-EM structure of human ME3 in the presence of citrateCryo-EM structure of human ME3 in the presence of citrate

Structural highlights

Function

See Also

References

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