NADP-dependent malic enzyme: Difference between revisions

Latest revision as of 12:11, 11 July 2023

<StructureSection load='3wja' size='340' side='right' caption='The best structure for NADP-dependent malic enzyme shown: 3wja' scene=> Best example is PDB entry 3wja and is shown in the viewer.

Catalytic ActivityCatalytic Activity

Oxaloacetate = pyruvate + CO(2).Data source: Uniprot P48163
Or the decarboxylation of malate to pyruvate^[1].

Biological processBiological process

Is involved in the following biological processes:
malate metabolic process
oxidation-reduction process
response to carbohydrate
response to hormone
carbohydrate metabolic process
protein tetramerization
regulation of NADP metabolic process
NADP biosynthetic process
small molecule metabolic process
cellular lipid metabolic process

In structuresIn structures

NADP-dependent malic enzyme is found in 3 PDB entries

Eukaryota (3 PDB entries):
- Homo sapiens (2 PDB entries):
  - 3wja
  - Title: The crystal structure of human cytosolic NADP(+)-dependent malic enzyme in apo form
  - 2.548 A resolution
  - Search the PDB for NADP-dependent malic enzyme from Homo sapiens
- Columba livia (1 PDB entries):
  - 1gq2
  - Title: MALIC ENZYME FROM PIGEON LIVER
  - 2.5 A resolution

Alternative names for NADP-dependent malic enzymeAlternative names for NADP-dependent malic enzyme

Molecule NADP-dependent malic enzyme, also known as NADP-ME, NADP-dependent malic enzyme and Malic enzyme 1.

3D Structures of NADP-dependent malic enzyme3D Structures of NADP-dependent malic enzyme

Updated on 11-July-2023

3wja, 2aw5 – hME - human
7x11, 7x12 – hME1 + NADP
8e76, 8eyn – hME3
8e78, 8e8o, 8eyo – hME3 + NADP
1gq2 – ME + NADP - pigeon
5ou5 – ME - maize

ReferencesReferences

↑ Loeber G, Dworkin MB, Infante A, Ahorn H. Characterization of cytosolic malic enzyme in human tumor cells. FEBS Lett. 1994 May 16;344(2-3):181-6. PMID:8187880

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

PDBe, Jaime Prilusky, Michal Harel

[1] Loeber G, Dworkin MB, Infante A, Ahorn H. Characterization of cytosolic malic enzyme in human tumor cells. FEBS Lett. 1994 May 16;344(2-3):181-6. PMID:8187880

[1]

@@ Line 1: / Line 1: @@
-== NADP-dependent malic enzyme ==
+<StructureSection load='3wja' size='340' side='right' caption='The best structure for NADP-dependent malic enzyme shown: [[3wja]]' scene=''>
-<StructureSection load='3wja' size='340' side='right' caption='Caption for this structure' scene=''>
+Best example is PDB entry [[3wja]] and is shown in the viewer.<br>
-Best example is 3wja<br>
+==Catalytic Activity ==
-Molecule NADP-dependent malic enzyme, also known as NADP-ME, NADP-dependent malic enzyme and Malic enzyme 1.
+Oxaloacetate = pyruvate + CO(2).Data source: Uniprot [http://www.uniprot.org/uniprot/P48163 P48163]<br>
+Or the decarboxylation of malate to pyruvate<ref>PMID:8187880</ref>.
-== Function ==
-electron carrier activity<br>
-NADP binding<br>
-ADP binding<br>
-oxaloacetate decarboxylase activity<br>
-NAD binding<br>
-metal ion binding<br>
-oxidoreductase activity<br>
-malate dehydrogenase (decarboxylating) (NADP+) activity<br>
-manganese ion binding<br>
-malate dehydrogenase (decarboxylating) (NAD+) activity<br>
-malic enzyme activity<br>
-== Disease ==
-== Relevance ==
-== Structural highlights ==
 == Biological process ==
 Is involved in the following biological processes:<br>
@@ Line 34: / Line 18: @@
 cellular lipid metabolic process<br>
 == In structures ==
-aw5<br>
+NADP-dependent malic enzyme is found in 3 PDB entries<br>
-gq2<br>
+*<b>Eukaryota</b> (3 PDB entries): <br>
-wja<br>
+**<b>Homo sapiens</b> (2 PDB entries): <br>
+***[[3wja]] <div class="pdb-prints 3wja"></div>
+***Title: The crystal structure of human cytosolic NADP(+)-dependent malic enzyme in apo form
+***2.548 A resolution
+***[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific_name:%22Homo%20sapiens%22&all_molecule_names:%22NADP-dependent%20malic%20enzyme%22&!chimera:y Search the PDB for NADP-dependent malic enzyme from Homo sapiens]
+**<b>Columba livia</b> (1 PDB entries): <br>
+***[[1gq2]] <div class="pdb-prints 1gq2"></div>
+***Title: MALIC ENZYME FROM PIGEON LIVER
+***2.5 A resolution
+== Alternative names for NADP-dependent malic enzyme ==
+Molecule '''NADP-dependent malic enzyme''', also known as '''NADP-ME''', '''NADP-dependent malic enzyme''' and '''Malic enzyme 1'''.
+== 3D Structures of NADP-dependent malic enzyme ==
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+[[3wja]], [[2aw5]] – hME - human<br />
+[[7x11]], [[7x12]] – hME1 + NADP<br />
+[[8e76]], [[8eyn]] – hME3<br />
+[[8e78]], [[8e8o]], [[8eyo]] – hME3 + NADP<br />
+[[1gq2]] – ME + NADP - pigeon<br />
+[[5ou5]] – ME - maize<br />
+== References ==
+<references/>
+[[Category:Topic Page]][[Category:PDBe]]