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==Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide== | ==Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide== | ||
<StructureSection load='4nnk' size='340' side='right' caption='[[4nnk]], [[Resolution|resolution]] 2.31Å' scene=''> | <StructureSection load='4nnk' size='340' side='right'caption='[[4nnk]], [[Resolution|resolution]] 2.31Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4nnk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NNK OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4nnk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NNK FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nnk OCA], [https://pdbe.org/4nnk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nnk RCSB], [https://www.ebi.ac.uk/pdbsum/4nnk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nnk ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/RS1_MYCTU RS1_MYCTU] Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity). | ||
==See Also== | |||
*[[Ribosomal protein S1|Ribosomal protein S1]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
[[Category: | [[Category: Cai Q]] | ||
[[Category: | [[Category: Lin D]] | ||
[[Category: | [[Category: Liu Y]] | ||
[[Category: | [[Category: Yang J]] | ||
Latest revision as of 11:57, 20 March 2024
Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamideStructural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide
Structural highlights
FunctionRS1_MYCTU Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity). See Also |
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