2xyh: Difference between revisions

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-==CASPASE-3:CAS60254719==
-<StructureSection load='2xyh' size='340' side='right' caption='[[2xyh]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
+==Caspase-3:CAS60254719==
+<StructureSection load='2xyh' size='340' side='right'caption='[[2xyh]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2xyh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XYH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XYH FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2xyh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XYH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XYH FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TQ9:5-CHLORO-4-OXOPENTANOIC+ACID'>TQ9</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nme|1nme]], [[1rhk|1rhk]], [[2j33|2j33]], [[1rhr|1rhr]], [[1nms|1nms]], [[1nmq|1nmq]], [[1rhq|1rhq]], [[1rhj|1rhj]], [[2cnn|2cnn]], [[2dko|2dko]], [[2c2k|2c2k]], [[2cjy|2cjy]], [[2j31|2j31]], [[2cnl|2cnl]], [[2c2m|2c2m]], [[2cnk|2cnk]], [[1cp3|1cp3]], [[2cjx|2cjx]], [[1re1|1re1]], [[2j30|2j30]], [[2xyg|2xyg]], [[2c1e|2c1e]], [[1pau|1pau]], [[2cdr|2cdr]], [[2j32|2j32]], [[1i3o|1i3o]], [[2cno|2cno]], [[1gfw|1gfw]], [[1rhu|1rhu]], [[1rhm|1rhm]], [[2c2o|2c2o]], [[1qx3|1qx3]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TQ9:5-CHLORO-4-OXOPENTANOIC+ACID'>TQ9</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-3 Caspase-3], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.56 3.4.22.56] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xyh OCA], [https://pdbe.org/2xyh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xyh RCSB], [https://www.ebi.ac.uk/pdbsum/2xyh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xyh ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xyh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xyh RCSB], [http://www.ebi.ac.uk/pdbsum/2xyh PDBsum]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 16: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2xyh" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Caspase|Caspase]]
+*[[Caspase 3D structures|Caspase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Caspase-3]]
 [[Category: Homo sapiens]]
-[[Category: Ganesan, R.]]
+[[Category: Large Structures]]
-[[Category: Grutter, M G.]]
+[[Category: Ganesan R]]
-[[Category: Jelakovic, S.]]
+[[Category: Grutter MG]]
-[[Category: Mittl, P R.]]
+[[Category: Jelakovic S]]
-[[Category: Apoptosis]]
+[[Category: Mittl PR]]
-[[Category: Docking]]
-[[Category: Hydrolase]]
-[[Category: In silico screening]]